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Post-Transplant Tremor: Characteristics and Differences Based on Sex and Post-Transplant Therapy
Srdjana Telarovic1,2, Maja Vrdoljak Pazur1,3, Nikolina Zupancic1,4
1School of Medicine, University of Zagreb, Salata 3b, 10000 Zagreb, Croatia.
Neurology International
|March 27, 2026
Summary
Post-transplant tremor affects 36% of kidney transplant recipients, particularly women using tacrolimus. This tremor typically resolves within a year and does not significantly impact quality of life.
Area of Science:
- Nephrology
- Neurology
- Pharmacology
Background:
- Kidney transplantation is standard for end-stage kidney disease.
- Neurological complications, including tremor, are frequent post-transplant.
- Tremor is often attributed to immunosuppressive drug toxicity.
Purpose of the Study:
- Investigate the incidence and characteristics of post-transplant tremor.
- Analyze factors associated with tremor development, focusing on calcineurin inhibitor neurotoxicity.
- Identify predictive factors and assess the impact on quality of life.
Main Methods:
- Retrospective study of 123 kidney transplant recipients.
- Analysis of demographic and clinical parameters.
- Univariable and multivariable statistical analyses.
Main Results:
- 36% of patients developed post-transplant tremor.
- Female sex and tacrolimus use were independent predictors.
- Younger age was also associated with tremor; symptoms resolved within 1 year.
Conclusions:
- Post-transplant tremor is common but generally benign.
- Female sex and tacrolimus are key predictors.
- Tremor resolves spontaneously within a year without significant quality of life impact.
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