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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
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Candidemia in Southern Poland (2017-2022): Multicenter Analysis of Species Distribution and Antifungal Susceptibility

Magdalena Namysł1, Magdalena Skóra2, Monika Pomorska-Wesołowska3

  • 1Department of Microbiology, University Hospital in Krakow, Jakubowskiego 2 Street, 30-688 Krakow, Poland.

Journal of Fungi (Basel, Switzerland)
|March 27, 2026
PubMed

Insights

This study analyzed 570 Candida strains from Polish hospitals (2017-2022). Candida albicans was most common, but resistance was noted in Nakaseomyces glabratus and Candida parapsilosis, highlighting the need for antifungal stewardship.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Clinical Microbiology

Background:

  • Invasive candidiasis is a significant threat, particularly in immunocompromised hospitalized patients.
  • Emerging non-albicans Candida species and antifungal resistance necessitate ongoing surveillance.
  • Accurate species identification and susceptibility testing are crucial for effective treatment.

Purpose of the Study:

  • To determine the species distribution of Candida causing candidemia in southern Poland from 2017-2022.
  • To assess the antifungal drug susceptibility patterns of isolated Candida strains.
  • To identify trends in non-albicans Candida prevalence and resistance.

Main Methods:

  • Retrospective analysis of 570 Candida-positive blood cultures from five hospitals.
  • Species identification of isolated Candida strains.
  • Antifungal susceptibility testing, focusing on fluconazole resistance.

Main Results:

  • Candida albicans was the most frequent species (42.6%).
  • Nakaseomyces glabratus (formerly Candida glabrata) and Candida parapsilosis complex were the next most common (22.1% and 18.8%).
  • Fluconazole resistance was observed in 4.9% of C. albicans, 34.7% of N. glabratus, and 8.7% of C. parapsilosis strains. No Candida auris was detected.

Conclusions:

  • Candida albicans remains the leading cause of candidemia in the studied region.
  • Significant fluconazole resistance rates were found in Nakaseomyces glabratus and Candida parapsilosis, underscoring treatment challenges.
  • Continuous monitoring of Candida species spectrum and antifungal resistance is essential for public health.
Keywords:
Candida spp.antifungal susceptibilitycandidemiafluconazoleinvasive candidiasis

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