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In Vitro and In Ovo CAM Model Evaluation of Periosteum-Derived Micrografts.

Rawan Almujaydil1,2, Conor J McCann3, Linh Nguyen4

  • 1Periodontology Unit, UCL Eastman Dental Institute, London WC1E 6DE, UK.

Journal of Functional Biomaterials
|March 27, 2026
PubMed
Summary

Periosteum-derived micrografts combined with dental bone substitutes significantly enhance vascularization in a chick embryo model. This suggests their potential to improve tissue regeneration and healing in periodontal therapies.

Keywords:
biocompatible materialscell- and tissue-based therapychorioallantoic membraneperiosteumregenerationtissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Periodontal Therapy

Background:

  • Periodontal regenerative therapies face challenges in achieving consistent tissue regeneration.
  • Cells are crucial for successful repair in periodontal regeneration.
  • Periosteum-derived micrografts offer a potential cell source for regenerative applications.

Purpose of the Study:

  • To evaluate the angiogenic potential of dental bone substitutes combined with periosteum-derived micrografts.
  • To assess the impact of these combinations on vascularization within a chorioallantoic membrane (CAM) model.
  • To characterize cell populations within the micrografts.

Main Methods:

  • Periosteum-derived micrografts were obtained using the Rigenera HBW system.
  • Micrografts were combined with dental bone substitutes (Fisiograft®, New Shore®, Bio-Oss®) and embedded in the CAM.
  • Angiogenesis was quantified using Ikosa software, with histological and immunohistochemical analyses (SMA, H&E, Masson's trichrome) performed.
  • Cell populations were identified via immunofluorescence and flow cytometry.

Main Results:

  • Periosteum-derived micrografts significantly enhanced vascularization compared to controls.
  • Combinations with Fisiograft®, New Shore®, and Bio-Oss® showed notable improvements in vessel area, length, and branching points.
  • Histological analysis confirmed increased vascularization, indicated by positive smooth muscle actin (SMA) staining.

Conclusions:

  • Periosteum-derived micrografts show promise as an adjunct to conventional bone grafting materials.
  • These micrografts promote vascularization, potentially improving tissue regeneration and healing outcomes in periodontal applications.