Two New Pentadepsipeptides from the Mangrove Fungus Aspergillus sp. SCSIO 41443

Area of Science:

• Natural Product Chemistry
• Marine Microbiology
• Biotechnology

Background:

• Mangrove fungi are rich sources of diverse natural products.
• Natural peptides from fungi have significant therapeutic and commercial value.
• These compounds are crucial for developing new drugs for various diseases.

Purpose of the Study:

• To isolate and characterize new cyclic depsipeptides from mangrove fungi.
• To evaluate the biological activities of isolated compounds.
• To explore the metabolic potential of mangrove-derived microorganisms.

Main Methods:

• Solid-state fermentation of mangrove fungi followed by extraction.
• Purification using silica gel vacuum liquid chromatography and HPLC.
• Structure elucidation via NMR, ESI-MS-MS, and Marfey's method.

Main Results:

• Two new compounds, aspertides F (1) and G (2), were identified.
• Three known compounds, aspertides C, D, and A (3-5), were also isolated.
• Compounds showed weak inhibitory activity against acetylcholinesterase and neuraminidase.

Conclusions:

• The study expands the known metabolic library of mangrove fungi.
• Identified compounds demonstrate the diverse biological activities of these fungi.
• Findings underscore the application potential of mangrove-derived natural products.