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Age-Related Associations of Foveal Structural Parameters in Healthy Adults: A Comparative Analysis of Biological and
Anait S Khalatyan1, Yusef Yusef1, Khadishat K Altemirova1
1Krasnov Research Institute of Eye Diseases, 11 A, B, Rossolimo St., Moscow 119021, Russia.
Background:
This research compared the relationship between foveal optical coherence tomography (OCT) parameters and two age measures-biological and chronological-in healthy adults.
Methods:
This cross-sectional study analyzed swept-source optical coherence tomography (OCT) data from 308 eyes of 154 healthy adults aged 22-89 years. Parameters assessed: foveal thickness, foveal pit depth and diameter, pit slope steepness, and the presence or absence of the foveal bulge. Biological age was calculated using the PhenoAge algorithm.
Results:
The core geometry of the foveal pit showed no significant dependence on either type of age (all p ≥ 0.66). In contrast, the foveal bulge prevalence declined significantly with age (adjusted p = 0.011 for chronological age, p = 0.005 for biological age; OR per year ≈0.95, 95% CI 0.92-0.98 for both age models). Model-predicted prevalence decreased from approximately 93% in younger adults to 60-68% in the 60-74-year-old group.
Conclusion:
The foveal architecture remains structurally stable throughout adulthood. The foveal bulge emerges as a sensitive qualitative marker of age-related changes. Biological age does not provide additional predictive value over chronological age for foveal structural parameters under physiological aging conditions.
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