Related Experiment Video
Updated: Mar 29, 2026
A Modified QuEChERS-HPLC Method for Detection of Polycyclic Aromatic Hydrocarbons in Zebrafish Embryos Exposed to Fine Particulate Matter
Published on: June 13, 2025
Associations Between Air Pollution Exposure and Gestational Weight Gain Pattern: Evidence from a Large-Scale
Shimin Xiong1,2, Wenting Ai1,2, Kunming Tian1,2
1School of Public Health, Zunyi Medical University, Zunyi 563000, China.
None:
Air pollution has been associated with dysregulated metabolism. However, evidence linking prenatal air pollution exposure to gestational weight gain (GWG) pattern remains limited. This retrospective cohort study of 47,793 pregnant women in Guiyang (2013-2022) assessed associations between air pollutants and GWG pattern. Positive associations were observed between excessive GWG and CO (per 1 μg/m3 increase), NO2, O3, PM10, PM2.5, and SO2 (per 10 μg/m3 increase) throughout the whole pregnancy period. Specifically, early-pregnancy exposure to CO (OR = 1.377, 95% CI: 1.201, 1.578) and NO2 (OR = 1.098, 95% CI: 1.068, 1.130), along with exposure to PM10 (OR = 1.058, 95% CI: 1.043, 1.073), PM2.5 (OR = 1.095, 95% CI: 1.073, 1.118), and SO2 (OR = 1.135, 95% CI: 1.102, 1.169) during late pregnancy significantly increased excessive GWG risk. Conversely, O3 exposure was inversely associated with excessive GWG. For insufficient GWG, only early-pregnancy exposures to PM10 (OR = 1.016, 95% CI: 1.001, 1.032), PM2.5 (OR = 1.022, 95% CI: 1.001, 1.043), and SO2 (OR = 1.031, 95% CI: 1.004, 1.058) showed significant positive associations. Furthermore, the restricted cubic spline (RCS) model revealed a nonlinear relationship between pollutant exposure and the risk of excessive GWG. Stratified analyses revealed that the air pollution and GWG (continuous) association was stronger among women with pre-pregnancy BMI ≥ 24 kg/m2 and aged ≥ 30 years. This study confirms that, even at lower concentrations, exposure to air pollutants during pregnancy is significantly associated with an increased risk of abnormal GWG. Compared to previous studies focusing on high-concentration areas, this finding provides additional evidence for assessing the health risks of air pollution exposure during pregnancy, suggesting that the potential metabolic effects of low-level, long-term exposure should be considered when developing maternal health strategies.
More Related Videos
05:18Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters
Published on: July 12, 2024
06:39Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Related Concept Videos
01:29Asthma-I: Introduction
01:23Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
01:20Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
01:07Teratogenicity
01:22Diabetes Mellitus: Type 2 and Gestational
02:27Background and Environment Affect Phenotype
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...