Retrospective Analysis of Compulsive-like Long-Standing Unacceptable Urination in Cats
Stefania Uccheddu1, Federica Pirrone2
1San Marco Veterinary Clinic and Laboratory, Via dell'Industria 3, 35030 Veggiano, Padua, Italy.
Veterinary Sciences
|March 27, 2026
Summary
Feline unacceptable elimination, when compulsive-like, significantly improved with clomipramine treatment. Behavioral modification alone showed limited success, suggesting clomipramine
Area of Science:
- Veterinary Behavior Medicine
- Feline Behavior Studies
- Compulsive Disorders in Animals
Background:
- Unacceptable elimination is a frequent feline behavioral issue.
- Repetitive and rigid elimination patterns may indicate compulsive-like behaviors.
- Medical causes must be excluded before diagnosing behavioral elimination problems.
Purpose of the Study:
- To describe cats with longstanding unacceptable urination exhibiting compulsive features.
- To compare the efficacy of behavioral modification alone versus combined with clomipramine for compulsive-like elimination in cats.
- To investigate clomipramine's potential role in treating compulsive-like elimination disorders in felines.
Main Methods:
- Retrospective case series of 21 cats with unacceptable urination and compulsive features.
- Exclusion of medical causes through physical examination and laboratory testing.
- Comparison of outcomes between behavioral modification alone (n=10) and behavioral modification plus clomipramine (n=11).
Main Results:
- A positive outcome was observed in 10/11 cats treated with clomipramine versus 1/10 cats receiving behavioral modification alone after 30 days.
- Follow-up completion rates were higher in the clomipramine group.
- Baseline characteristics were comparable between the two treatment groups.
Conclusions:
- Findings suggest a pattern of compulsive-like elimination in cats with specific behavioral traits.
- Clomipramine, in conjunction with behavioral modification, appears highly effective for treating compulsive-like elimination in cats.
- The positive response to clomipramine supports its use and the conceptual framework of compulsive-like elimination disorders in felines.
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