Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

308
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
308
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

429
Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
429
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

302
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
302
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

1.9K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.9K
Factors Influencing Bioavailability: First-Pass Elimination01:23

Factors Influencing Bioavailability: First-Pass Elimination

8.6K
When a drug is taken orally, it undergoes a journey starting from the gastrointestinal (GI) tract, passing through the portal vein, reaching the liver, and finally entering the systemic circulation. This process involves the absorption of the drug across the GI tract. The liver is the primary site for metabolizing the drug, with some metabolism also occurring in the gut wall. This journey significantly reduces the quantity of the drug that reaches the systemic circulation, a phenomenon known as...
8.6K
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems01:22

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

324
Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...
324

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fermentation of plant-based foods: Microbial consortia and their impacts on composition, sensory quality, and health benefits of food products.

Advances in food and nutrition research·2026
Same author

Inhibition of Ice Recrystallization by Regulating the Surface Free Energy of Nanoparticles.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Anaerobic metabolic evolution for homotypic L-valine fermentation.

Nature communications·2026
Same author

A lipidomics roadmap: from basic research to societal challenges.

Nature communications·2026
Same author

De Novo Engineering of <i>Escherichia coli</i> for an l-Lysine Hyperproducer.

Journal of agricultural and food chemistry·2026
Same author

Induction of regulatory T cells by an aluminum-CpG combination adjuvant for therapeutic and preventive vaccination against pollen allergy.

Journal of controlled release : official journal of the Controlled Release Society·2026

Related Experiment Video

Updated: Mar 29, 2026

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

10.6K

Fucoxanthin: A Comprehensive Review on Digestion, Biotransformation, Microbiome Interaction, and Targeted Delivery.

Bingbing Sun1,2,3, Chunjie Zhao1,2,3, Xiao Chen4

  • 1College of Food Science and Engineering, Ningbo University, Ningbo 315211, China.

Journal of Agricultural and Food Chemistry
|March 27, 2026
PubMed
Summary
This summary is machine-generated.

Fucoxanthin, a marine carotenoid, is metabolized in the gut and liver, impacting gut microbes. This review explores its fate and delivery systems for enhanced health applications.

Keywords:
bioavailabilitydelivery systemfucoxanthingut microbiotametabolism

More Related Videos

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

3.6K
3D Flipwell Engineering for Developing Asynchronous Systems for Toxicologic and Immunomodulatory Therapies in Bacterial, Gut, and Immune Cells
11:00

3D Flipwell Engineering for Developing Asynchronous Systems for Toxicologic and Immunomodulatory Therapies in Bacterial, Gut, and Immune Cells

Published on: October 17, 2025

493

Related Experiment Videos

Last Updated: Mar 29, 2026

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

10.6K
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

3.6K
3D Flipwell Engineering for Developing Asynchronous Systems for Toxicologic and Immunomodulatory Therapies in Bacterial, Gut, and Immune Cells
11:00

3D Flipwell Engineering for Developing Asynchronous Systems for Toxicologic and Immunomodulatory Therapies in Bacterial, Gut, and Immune Cells

Published on: October 17, 2025

493

Area of Science:

  • Marine natural products
  • Nutritional science
  • Pharmacokinetics

Background:

  • Fucoxanthin is a marine carotenoid with significant health benefits.
  • Its gastrointestinal fate, metabolism, and delivery systems require further investigation for effective application.
  • Understanding fucoxanthin's bioactivity is crucial for developing functional foods and therapeutics.

Purpose of the Study:

  • To review the current understanding of fucoxanthin's digestion and biotransformation.
  • To summarize fucoxanthin's tissue distribution and interaction with gut microbiota.
  • To compare various delivery systems for improving fucoxanthin's bioavailability.

Main Methods:

  • Literature review of in vivo and in vitro studies on fucoxanthin metabolism.
  • Analysis of studies on fucoxanthin's effects on gut microbial composition.
  • Comparison of different fucoxanthin delivery systems (lipid-, polysaccharide-, protein-based).

Main Results:

  • Fucoxanthin is hydrolyzed to fucoxanthinol in the intestine and converted to amarouciaxanthin A in the liver.
  • Metabolites are distributed to plasma, liver, adipose tissue, and heart.
  • Fucoxanthin exhibits a duplibiotic effect, modulating gut microbiota and linking metabolism to host-microbiota interactions.

Conclusions:

  • Fucoxanthin undergoes extensive metabolism in the gastrointestinal tract and liver.
  • Fucoxanthin influences the gut microbiome, suggesting a role in host-microbiota interactions.
  • Development of advanced delivery systems is essential to overcome low oral bioavailability and enhance fucoxanthin's therapeutic potential.