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    Area of Science:

    • X-ray imaging
    • Materials science
    • Biological imaging

    Background:

    • Propagation-based phase-contrast imaging advances visualization of large samples.
    • Modulation-based techniques offer quantitative electron density but struggle with large objects due to beam stability and detector issues.
    • Expanding the field of view is vital for quantitative results and adapting to new synchrotron sources.

    Purpose of the Study:

    • To develop a novel image processing technique for quantitative high-resolution imaging of centimeter-sized objects.
    • To overcome limitations in field of view for modulation-based phase-contrast imaging.
    • To enable quantitative electron density mapping of large samples.

    Main Methods:

    • Introduced a novel image processing technique.
    • Combined eigenflat optimization with deformable image registration.
    • Applied the technique to scan centimeter-sized objects with multi-micrometer resolution.

    Main Results:

    • Successfully obtained a quantitative electron density map of a 15mm rat brain sample.
    • Demonstrated high-resolution scanning despite a limited 6mm horizontal field of view.
    • Showcased the technique's ability to widen applications for modulation-based imaging.

    Conclusions:

    • The novel image processing technique effectively addresses challenges in imaging large objects.
    • This method significantly expands the applicability of modulation-based phase-contrast imaging in diverse research fields.
    • Enables quantitative analysis of centimeter-sized biological and material samples with high resolution.