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Updated: Mar 29, 2026
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Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
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Idiopathic Mesenteric Phlebosclerosis Presenting as Recurrent Diarrhea
Ling Xiao1, Hong Li2, Fei-Fan Chen3
1Department of Gastroenterology, West China Tianfu Hospital, Sichuan University, Chengdu, Sichuan Province, China. xl_522522@163.com.
Journal of Gastrointestinal and Liver Diseases : JGLD
|March 27, 2026
Summary
This study reports a rare case of idiopathic mesenteric phlebosclerosis (IMP) linked to traditional Chinese herb consumption. Findings suggest Gardenia Fructus may contribute to venous wall fibrosis and chronic intestinal ischemia.
Area of Science:
- Gastroenterology
- Vascular Medicine
- Pharmacology
Background:
- Idiopathic mesenteric phlebosclerosis (IMP) is a rare condition.
- Recurrent abdominal pain and diarrhea can be symptoms of IMP.
- Traditional herbal remedies may have uncharacterized adverse effects.
Purpose of the Study:
- To present a rare case of idiopathic mesenteric phlebosclerosis (IMP).
- To investigate the potential link between traditional Chinese herb intake and IMP development.
- To raise awareness among clinicians regarding potential herbal remedy risks.
Main Methods:
- Clinical investigation including laboratory tests.
- Diagnostic procedures: colonoscopy, biopsy, and enhanced abdominal computed tomography angiography (CTA).
- Literature review on Gardenia Fructus and its components.
Main Results:
- A 73-year-old woman diagnosed with IMP.
- A potential association identified between long-term Gardenia Fructus intake and IMP.
- Genipin, a Gardenia Fructus component, is implicated in venous wall intimal hyperplasia and fibrosis.
Conclusions:
- Herbal intake, specifically Gardenia Fructus, should be considered a potential risk factor for IMP.
- Clinicians must be aware of the potential adverse effects of traditional herbal remedies.
- Further research is warranted to elucidate the mechanisms linking herbal components to vascular pathology.
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