Related Experiment Video

Updated: Mar 29, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

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Incremental prognostic value of left atrial strain for heart failure-related events following ST-Segment elevation

Yun Zhao1, Xing-Yu Chen1, Guo-Jun Zhu1

  • 1Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

European Journal of Radiology
|March 27, 2026
PubMed

Insights

Left atrial reservoir strain, measured by cardiac MRI, predicts heart failure (HF) events after ST-elevation myocardial infarction (STEMI). This metric improves risk assessment for HF, even in patients with normal ejection fraction.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Heart failure (HF) following acute myocardial infarction (AMI) leads to high mortality and rehospitalization.
  • Left ventricular ejection fraction (LVEF) at discharge is an insufficient predictor of cardiac function post-AMI.
  • Patients with normal LVEF at discharge remain at significant risk for developing HF.

Purpose of the Study:

  • To evaluate the utility of left atrial (LA) strain from cardiac MRI for risk stratification of HF events in ST-segment elevation myocardial infarction (STEMI) patients.
  • To assess LA strain's value across various LVEF levels in STEMI survivors.

Main Methods:

  • Retrospective analysis of 1531 STEMI patients undergoing cardiac MRI.
  • Composite endpoint included all-cause death, HF-related events (hospitalization/transplant), reinfarction, and revascularization.
  • Follow-up median of 50.9 months.

Main Results:

  • Reduced LA reservoir strain (<23%) was independently linked to increased HF-related events (HR 0.93, P<0.001).
  • LA conduit strain also predicted HF events (HR 0.94, P=0.02).
  • Preserved LA reservoir function (≥23%) indicated low HF risk irrespective of LVEF.

Conclusions:

  • Reduced LA reservoir strain is a significant independent predictor of HF events in STEMI patients.
  • LA strain analysis enhances risk stratification beyond LVEF for HF development.
  • This imaging biomarker may guide clinical therapeutic decisions for STEMI survivors.
Abstract

Keywords:
Cardiac magnetic resonanceHeart failureLeft atrialMyocardial infarctionRisk stratification

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