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Cardiovascular Disease and Sudden Cardiac Arrest in Young Individuals: An Evolving Challenge

Jaya Singh1, Nidhi Jatana1

  • 1Department of Biotechnology, Jaypee Institute of Information Technology, Noida, India.

The American Journal of Cardiology
|March 27, 2026
PubMed

Insights

Sudden cardiac arrest (SCA) is a major global health issue, particularly affecting younger individuals. Early detection through genetic testing and public awareness are crucial for improving survival rates and preventing tragic deaths.

Area of Science:

  • Cardiology
  • Public Health
  • Genetics

Background:

  • Cardiovascular diseases (CVD) are the leading cause of global mortality, with sudden cardiac arrest (SCA) posing a significant and growing threat.
  • SCA disproportionately affects younger populations, often due to inherited arrhythmias and conditions like hypertrophic cardiomyopathy (HCM), unlike older adults where coronary artery disease is more common.

Purpose of the Study:

  • To review the epidemiology, trends, and preventive strategies for sudden cardiac arrest (SCA), with a focus on younger individuals.
  • To emphasize the critical need for early detection, family screening, and genetic testing in managing SCA risks.

Main Methods:

  • This review synthesizes existing evidence on SCA epidemiology and trends.
  • It examines current and potential preventive strategies, including genetic testing and public health initiatives.

Main Results:

  • Survival rates after SCA remain critically low despite medical advancements.
  • Inherited conditions are primary drivers of SCA in individuals under 50.
  • Early detection via family screening and genetic testing is vital.

Conclusions:

  • Integrating precision medicine, public health campaigns, and targeted awareness programs is essential to combat the rising global burden of SCA in young people.
  • Proactive identification of at-risk individuals through genetic screening can mitigate the impact of SCA.

Keywords:
Arrythmiascardiomyopathiescardiovascular diseaseshypertrophic cardiomyopathysudden cardiac arrest

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