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Primary cilia regulate GLP-1 signaling in pancreatic β cells

Isabella Melena1, Jeong Hun Jo2, Shannon E Townsend2

  • 1Department of Medicine, Division of Endocrinology, Metabolism & Lipid Research, Washington University School of Medicine, St. Louis, MO 63110, USA.

Molecular Metabolism
|March 27, 2026
PubMed
Summary

Primary cilia are essential for glucagon-like peptide-1 receptor (GLP-1R) signaling in beta cells. Their absence impairs insulin secretion, revealing a critical role for these cellular structures in incretin hormone action.

Keywords:
GLP-1Insulin secretionPrimary cilia

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