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Updated: Mar 29, 2026
Biomimetic Materials to Characterize Bacteria-host Interactions
Published on: November 16, 2015
A mussel-inspired dynamic cross-linking design for eco-friendly, injectable, and bactericidal biomass-based
Yinghui Li1, Xueping Wang2, Yulin Liu2
1Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China; CAS Key Laboratory of Magnetic Materials and Devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, Zhejiang, China.
Abstract:
Tissue adhesives have emerged as promising alternatives to sutures for wound closure, yet integrating robust wet adhesion with antibacterial activity, biocompatibility, and biodegradation remains a significant challenge. Herein, we report a fully biomass-derived, mussel-inspired adhesive (Tyr-Pec/QX/Alg) constructed through multi-dynamic crosslinking of cationized xylan from bagasse pith, tyrosine-grafted pectin from jackfruit, and alginate. The network, enabled by reversible hydrophobic, cation-π/anion-π, hydrogen bonding, and electrostatic interactions, confers excellent shear-thinning injectability and strong adhesion to wet tissues, achieving adhesion strengths of 43.0 kPa on porcine skin, 77.9 kPa on cloth, and 7.3 kPa on PDMS, outperforming commercial fibrin and cyanoacrylate glues. The adhesive also exhibits broad-spectrum antibacterial efficacy (inhibition rates of 94.5% against E. coli and 86.2% against S. aureus), high moisture retention (32.36% reduction in water loss over 7 days), excellent cytocompatibility (93.1% cell viability), and full biodegradability. Ex vivo experiments confirm rapid and leak-proof sealing of perforated organ tissues within seconds. This multifunctional hydrogel presents a scalable and sustainable strategy for suture-free wound management in demanding surgical and biomedical applications.
