Clinical Outcomes of the Optimized Weekly 8-Gy Palliative Radiotherapy Regimen

Area of Science:

• Oncology
• Radiation Oncology
• Palliative Care

Background:

• The
• optimized weekly 8 regimen
• (8-Gy fraction once weekly for 3-4 fractions) is utilized for palliative radiotherapy.
• This retrospective study evaluates its efficacy and safety.

Purpose of the Study:

• To assess treatment outcomes of the
• optimized weekly 8 regimen
• in palliative radiotherapy.
• To evaluate adverse events and clinical responses.

Main Methods:

• Retrospective review of patients receiving the
• optimized weekly 8 regimen
• between August 2023 and June 2024.
• Assessment of symptom relief, objective tumor response, and adverse events.

Main Results:

• 45 lesions in 42 patients were analyzed; 26 in head and neck.
• Symptom relief in 76% (29/38) and objective tumor response in 48% (12/25) of evaluable lesions.
• Patients receiving ≥24 Gy showed 93% symptom relief and 75% tumor response in head and neck cancers. Grade 3 mucositis occurred in one patient; no grade ≥4 adverse events were observed.

Conclusions:

• The
• optimized weekly 8 regimen
• is a well-tolerated palliative radiotherapy option.
• It demonstrates significant symptom relief and tumor response, particularly in head and neck cancer patients.
• The regimen is associated with minimal severe adverse events.