Related Experiment Video
Updated: Mar 29, 2026

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
Published on: March 31, 2016
Locked-in syndrome
1Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
None:
The prerequisites for the locked-in stste are the presence of two components: one negative-sufficient paralysis of structures that render usual communications (mouth and oral apparatus for speech, and limbs for writing and pointing accurately) and one positive- preservation of consciousness. Lesions of the pontine base cause the syndrome. The most common pontine lesions are infarction related to basilar artery occlusion and pontine hemorrhages. Occasionally midbrain vascular lesions can cause the syndrome.
Related Concept Videos
Long-term Depression
Calcium Ion Concentration Mechanism
If over...
Long-term Depression
Local Anesthetics: Mechanism of Action
Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...
Long-term Potentiation

