Related Experiment Video
Updated: Mar 29, 2026

Metabolic Pathway Confirmation and Discovery Through 13C-labeling of Proteinogenic Amino Acids
Published on: January 26, 2012
Interplays and functional divergences of one-carbon metabolic shunts
Zhen Wang1, Weiwei Yu2, Di Wang3
1Zhejiang Key Laboratory of Precise Diagnosis and Treatment of Abdominal Infection, Sir Run Run Shaw Hospital, and Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, PR China; Zhejiang Key Laboratory of Imaging and Interventional Medicine, Department of Radiology, Lishui Central Hospital, Lishui Hospital of Zhejiang University, Lishui 323000, PR China.
Abstract:
One-carbon (1C) metabolism serves as a central hub governing anabolism-supporting and epigenetic modification processes through its shunts, the tetrahydrofolate (THF) cycle, and the methionine cycle. The 1C shunts exhibit divergent characteristics in mammalian cells in terms of methyl sources, regulatory networks, and supporting functions. Under specific physiological and pathological contexts, 1C metabolic shunts exhibit distinct biological functions and orchestrate metabolic crosstalk between cells and across organs. These findings have significantly advanced our understanding of systemic compartmentalization and functional cooperation between the divergent 1C shunts. In this review, we explore the intricate interplays and divergent biological roles between the THF and methionine cycles at the molecular, cellular, and systemic levels and further propose innovative avenues for research and clinical applications.
More Related Videos
Related Concept Videos
Carbohydrate Catabolism
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Carbohydrate Metabolism
Metabolism of Chemolithotrophs
Other Glycolytic Pathways

