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Related Concept Videos

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The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
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Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
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Loose connective tissue is found between many organs. Its main function is to absorb shock and bind tissues together. It also allows water, salts, and various nutrients to diffuse into cells that are embedded in it or present in adjacent tissues.
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Related Experiment Video

Updated: Mar 29, 2026

Identification and Dissection of Diverse Mouse Adipose Depots
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Exploring cell types and their dynamic states in adipose tissue.

Hahn Nahmgoong1, Jae Bum Kim1

  • 1National Leader Research Initiatives Center for Adipocyte Structure and Function, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University, Seoul 08826, Republic of Korea.

Trends in Endocrinology and Metabolism: TEM
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Summary

Adipose tissue

Keywords:
adipose tissuecell statecell subpopulationcell typecellular heterogeneitysingle-cell transcriptomics

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Area of Science:

  • Cellular Biology
  • Metabolic Research
  • Tissue Engineering

Background:

  • Adipose tissue exhibits functional versatility driven by diverse cell types.
  • Pathophysiological stimuli induce transitions between cellular functional states.
  • Single-cell transcriptomics reveals novel cell types and states within adipose tissue.

Purpose of the Study:

  • To review current knowledge on heterogeneous cell types and states in adipose tissue.
  • To discuss emerging techniques for characterizing these cells.
  • To provide fundamental insights for adipose tissue research in the single-cell era.

Main Methods:

  • Single-cell transcriptomics
  • Cellular state analysis
  • Review of emerging characterization techniques

Main Results:

  • Identification of numerous novel cell types and states in adipose tissue.
  • Characterization of adipocytes, adipose stem/progenitor cells, immune, vascular, and mesothelial cells.
  • Elucidation of cellular mechanisms underlying adipose tissue plasticity.

Conclusions:

  • Adipose tissue is a highly heterogeneous organ with dynamic cellular populations.
  • Single-cell technologies are crucial for understanding adipose tissue complexity.
  • This review consolidates knowledge for future adipose tissue research.