Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Determinants of Bacterial Pathogenicity and Virulence

Determinants of Bacterial Pathogenicity and Virulence

Pathogenic bacteria employ a variety of strategies to establish infections, including the secretion of extracellular enzymes that act as potent virulence factors. These enzymes facilitate bacterial colonization of host tissues and help evade immune surveillance. By targeting structural components of host tissues and interfering with immune mechanisms, these enzymes play a pivotal role in disease progression.Extracellular Enzymes Facilitating Tissue Invasion: Several bacterial pathogens secrete...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical efficacy and platform-specific analysis of robotic navigation systems in adolescent idiopathic scoliosis: a meta-analysis.

Journal of robotic surgery·2026

Same author

Comparative clinical performance of robotic-assisted systems in spinal deformity surgery: focus on perioperative outcomes and pedicle screw accuracy.

Journal of robotic surgery·2026

Same author

Trivalent GalNAc-Mediated Delivery of Cucurbitacin B Overcomes Systemic Toxicity for Potent HCC Chemoradiotherapy.

Biomacromolecules·2026

Same author

Downregulation of Organ-Derived Activin A Attenuates Muscle Atrophy and Intramuscular Fat Infiltration in Cancer Cachexia Mice.

Journal of cachexia, sarcopenia and muscle·2026

Same author

Maternal genetic structure and population affinities of the Sichuan Han Chinese based on whole mitochondrial genomes.

BMC genomics·2026

Same author

Insights into uranium enrichment of indigenous electroactive <i>Shewanella putrefaciens</i>.

Frontiers in microbiology·2026

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

The Terroir Concept Interpreted through Grape Berry Metabolomics and Transcriptomics

The Terroir Concept Interpreted through Grape Berry Metabolomics and Transcriptomics

Published on: October 5, 2016

Genomic and Transcriptomic Analyses Provide Insights Into Erysiphe necator Pathogenicity and Grapevine Response.

Bo Mu^1,2,3, Ruixin Tang^1,2,3, Zhaolin Teng^1,2,3

¹Hainan Institute of Northwest A&F University, Sanya, Hainan, China.

Plant Biotechnology Journal

|March 27, 2026

Summary

This study reveals how the fungus Erysiphe necator suppresses grapevine immunity using effector proteins like CSEP118. It also identifies VviTCP14 as a key regulator of grapevine resistance to powdery mildew.

Keywords:

CSEP118 RNA‐seq VviTCP14 genome grapevine powdery mildew

More Related Videos

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine

Published on: December 22, 2017

Author Spotlight: Exploring the Fermentation Microbiome Through Next-Generation Sequencing

Author Spotlight: Exploring the Fermentation Microbiome Through Next-Generation Sequencing

Published on: December 1, 2023

Related Experiment Videos

Last Updated: Jul 7, 2026

The Terroir Concept Interpreted through Grape Berry Metabolomics and Transcriptomics

The Terroir Concept Interpreted through Grape Berry Metabolomics and Transcriptomics

Published on: October 5, 2016

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine

Published on: December 22, 2017

Author Spotlight: Exploring the Fermentation Microbiome Through Next-Generation Sequencing

Author Spotlight: Exploring the Fermentation Microbiome Through Next-Generation Sequencing

Published on: December 1, 2023

Area of Science:

Plant Pathology
Fungal Genomics
Molecular Plant-Microbe Interactions

Background:

Grapevine powdery mildew, caused by Erysiphe necator, significantly impacts grape production.
Limited research exists on E. necator pathogenicity and grapevine defense mechanisms.

Purpose of the Study:

To elucidate the molecular mechanisms of Erysiphe necator pathogenicity.
To understand grapevine immune responses and resistance regulation against powdery mildew.

Main Methods:

Genome assembly of E. necator NAFU1.
RNA-Seq analysis of pathogen and host during infection.
Comparative transcriptome analysis of resistant and susceptible grapevines.
Gene silencing of VviTCP14 in grapevine.

Main Results:

Identified 248 candidate-secreted effector proteins (CSEPs) in E. necator.
CSEP118 was found to suppress grapevine defense by targeting VviTrxz.
VviTCP14 acts as a negative regulator of grapevine resistance, with its silencing enhancing defense gene expression.

Conclusions:

Uncovered E. necator effector-triggered immune suppression mechanisms.
Identified VviTCP14 as a crucial regulator for enhancing grapevine resistance to powdery mildew.
Provides insights for developing disease-resistant grapevines.