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The effectiveness of chemonucleolysis with condoliase for lumbar disc herniation in elderly patients over 70 years

Shu Takeuchi1,2, Toshiyuki Takahashi3, Tomoo Inoue3,4

  • 1Spinal Disorders Center, Fujieda Heisei Memorial Hospital, Fujieda, Shizuoka, Japan. shu.tk.0804@gmail.com.

Neurosurgical Review
|March 28, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
AgedChemonucleolysisCondoliaseEffectivenessElderlyLumbar disc herniation

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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