Related Experiment Video

Updated: Mar 29, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

11.1K

Role of Serum Inflammatory Biomarkers in Risk Stratification of Hospitalized Children with Macrolide-Non-Responsive

Jin-Sung Park1, Hyo-Bin Kim2

  • 1Department of Pediatrics, Kangwon National University School of Medicine, Kangwon National University Hospital, Chuncheon 24341, Republic of Korea.

Children (Basel, Switzerland)
|March 28, 2026
PubMed
Abstract

Insights

Elevated serum inflammatory biomarkers like ferritin may help identify children with Mycoplasma pneumoniae pneumonia who won't respond to macrolide treatment early. Combined biomarker assessment improves risk evaluation for macrolide-non-responsive pneumonia.

Area of Science:

  • Pediatric Infectious Diseases
  • Respiratory Medicine
  • Clinical Biomarkers

Background:

  • Macrolides are first-line treatment for Mycoplasma pneumoniae pneumonia (MPP) in children.
  • Increasing rates of macrolide-non-responsive MPP (MNMP) necessitate early identification of at-risk patients.
  • Identifying predictive biomarkers for MNMP is crucial for timely intervention.

Purpose of the Study:

  • To investigate serum inflammatory biomarkers for early risk stratification of macrolide non-responsiveness in pediatric MPP.
  • To identify specific biomarkers associated with clinically defined MNMP.

Main Methods:

  • Retrospective cohort study of 93 children hospitalized with MPP.
  • Classification into macrolide-sensitive (MSMP) and macrolide-non-responsive (MNMP) groups based on clinical response.
  • Comparison of admission serum biomarkers (PCT, CRP, LDH, ferritin, ESR) between groups.
  • Multivariable logistic regression to assess risk factors for MNMP.

Main Results:

  • Higher admission levels of C-reactive protein (CRP), ferritin, and erythrocyte sedimentation rate (ESR) in the MNMP group.
  • Elevated serum ferritin levels significantly associated with increased risk of MNMP.
  • Simultaneous elevation of multiple inflammatory biomarkers correlated with higher MNMP risk.

Conclusions:

  • Serum inflammatory biomarkers can aid in the early risk stratification of children with clinically defined macrolide non-responsiveness.
  • Combined assessment of multiple biomarkers may enhance the early evaluation of MNMP risk.
  • These findings support the use of inflammatory markers for personalized treatment strategies in pediatric MPP.
Keywords:
Mycoplasma pneumoniabiomarkersdiagnosispediatric pneumoniatreatment non-responsiveness

More Related Videos

Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae06:04

Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae

Published on: February 24, 2023

3.0K

Related Concept Videos

Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
1.2K
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
37
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
95