Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sublingual and Buccal Delivery: A Historical and Scientific Prescriptive.

Pharmaceutics·2025

Same author

An Update on Pharmaceutical Strategies for Oral Delivery of Therapeutic Peptides and Proteins in Adults and Pediatrics.

Children (Basel, Switzerland)·2020

Same author

Bioavailability testing of a newly developed clindamycin oral suspension in a pediatric porcine model.

Pharmaceutical development and technology·2019

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 29, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Microneedles: Selected Applications for Pediatrics.

Alexis A Ayala¹, Hassan Almoazen¹

¹Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 881 Madison Ave, Memphis, TN 38103, USA.

Children (Basel, Switzerland)

|March 28, 2026

Summary

Microneedles offer a pediatric-friendly approach for delivering large molecules like proteins and vaccines through the skin. This innovative drug delivery system shows promise for expanded applications in various body sites.

Keywords:

delivery diagnostic microneedles pediatrics vaccine

More Related Videos

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole

Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole

Published on: December 5, 2025

Related Experiment Videos

Last Updated: Mar 29, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole

Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole

Published on: December 5, 2025

Area of Science:

Biomedical Engineering
Dermatology
Pediatric Medicine

Background:

Microneedles are a novel drug delivery system gaining traction in pediatric research.
They create micro-cavities in the epidermis, facilitating the transdermal delivery of large molecules.

Purpose of the Study:

To review the pediatric applications of microneedle technology.
To highlight the advantages of microneedles for transdermal delivery of various therapeutic agents.

Main Methods:

Literature review of microneedle research in pediatric drug delivery.
Analysis of microneedle capabilities for delivering proteins, vaccines, and diagnostic agents.

Main Results:

Microneedles enable the transdermal delivery of peptides, proteins, nucleotides, and other large molecules.
Specific pediatric applications include vaccine and diagnostic delivery.

Conclusions:

Microneedle technology presents significant advantages for pediatric drug delivery.
Future applications are expected to expand beyond the skin to other body sites.