Real-World Treatment Patterns and Determinants of Therapy in Pediatric Atopic Dermatitis: A 10-Year Experience from a

Nuttida Yusakda1, Leelawadee Techasatian1, Piyadarat Asawasakulchokedee1

  • 1Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40000, Thailand.

Insights

Pediatric atopic dermatitis (AD) management relies heavily on conventional treatments, with limited access to advanced therapies. Age and healthcare coverage significantly impact treatment choices, underscoring the need for equitable access to care.

Area of Science:

  • Dermatology
  • Pediatrics
  • Real-world evidence

Background:

  • Atopic dermatitis (AD) is a chronic pediatric skin condition requiring long-term management.
  • Limited real-world data exists on current treatment patterns for pediatric AD.

Purpose of the Study:

  • To analyze treatment trends in pediatric AD.
  • To identify factors influencing the use of topical non-steroidal medications in children with AD.

Main Methods:

  • Retrospective analysis of 3982 pediatric AD patients from 2015-2024.
  • Review of demographic data, healthcare coverage, and prescribed treatments.
  • Multivariable logistic regression to determine predictors of topical non-steroidal agent use.

Main Results:

  • Conventional therapies like antihistamines and topical corticosteroids were most common.
  • Topical non-steroidal agents (including calcineurin inhibitors, PDE4 inhibitors, JAK inhibitors) were used in 12.7% of patients.
  • Adolescents received fewer topical non-steroidals than infants; patients with Civil Servant Medical Benefit Scheme (CSMBS) had greater access than those with Universal Coverage Scheme (UCS).

Conclusions:

  • Pediatric AD treatment predominantly uses conventional therapies, with restricted access to advanced options.
  • Age and healthcare coverage significantly shape prescribing patterns.
  • There is a critical need to improve equitable access to advanced AD treatments for children.
Abstract

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