Real-World Treatment Patterns and Determinants of Therapy in Pediatric Atopic Dermatitis: A 10-Year Experience from a Tertiary Referral Center in Thailand
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Nuttida Yusakda1, Leelawadee Techasatian1, Piyadarat Asawasakulchokedee1
1Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40000, Thailand.
Insights
Pediatric atopic dermatitis (AD) management relies heavily on conventional treatments, with limited access to advanced therapies. Age and healthcare coverage significantly impact treatment choices, underscoring the need for equitable access to care.
Area of Science:
- Dermatology
- Pediatrics
- Real-world evidence
Background:
- Atopic dermatitis (AD) is a chronic pediatric skin condition requiring long-term management.
- Limited real-world data exists on current treatment patterns for pediatric AD.
Purpose of the Study:
- To analyze treatment trends in pediatric AD.
- To identify factors influencing the use of topical non-steroidal medications in children with AD.
Main Methods:
- Retrospective analysis of 3982 pediatric AD patients from 2015-2024.
- Review of demographic data, healthcare coverage, and prescribed treatments.
- Multivariable logistic regression to determine predictors of topical non-steroidal agent use.
Main Results:
- Conventional therapies like antihistamines and topical corticosteroids were most common.
- Topical non-steroidal agents (including calcineurin inhibitors, PDE4 inhibitors, JAK inhibitors) were used in 12.7% of patients.
- Adolescents received fewer topical non-steroidals than infants; patients with Civil Servant Medical Benefit Scheme (CSMBS) had greater access than those with Universal Coverage Scheme (UCS).
Conclusions:
- Pediatric AD treatment predominantly uses conventional therapies, with restricted access to advanced options.
- Age and healthcare coverage significantly shape prescribing patterns.
- There is a critical need to improve equitable access to advanced AD treatments for children.
Background:
Atopic dermatitis (AD) is a chronic inflammatory skin disease in children requiring long-term management, yet real-world data on treatment patterns remain limited.
Objective:
To evaluate treatment trends and factors associated with topical non-steroidal medication use in pediatric AD.
Methods:
We retrospectively analyzed 3982 children with AD treated at a tertiary referral center in Thailand between 2015 and 2024. Demographic data, healthcare coverage, and prescribed treatments were reviewed. Multivariable logistic regression was used to identify factors associated with topical non-steroidal use.
Results:
The median age was 7 years, with no sex difference. The most commonly prescribed treatments were antihistamines (75.0%), topical corticosteroids (47.6%), moisturizers (43.9%), systemic immunosuppressants (15.7%), topical non-steroidal agents including topical calcineurin inhibitors, phosphodiesterase-4 inhibitors, and Janus kinase (JAK) inhibitors (12.7%), and biologics (0.1%). Moderate-potency corticosteroids predominated. Adolescents were less likely to receive topical non-steroidal agents than infants (OR 0.66, 95% CI 0.50-0.87), whereas patients under the Civil Servant Medical Benefit Scheme (CSMBS) had higher access than those under the Universal Coverage Scheme (UCS) (OR 8.40, 95% CI 5.76-12.25).
Conclusions:
Pediatric AD management was dominated by conventional therapies, with limited access to advanced treatments. Age and healthcare coverage strongly influenced prescribing patterns, highlighting the need for more equitable access.
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