Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Teratogenicity01:07

Teratogenicity

4.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.5K
Fetal Circulation01:14

Fetal Circulation

4.5K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
4.5K
Adrenergic Antagonists: ɑ and β-Receptor Blockers01:31

Adrenergic Antagonists: ɑ and β-Receptor Blockers

1.4K
Third-generation β-blockers, such as labetalol and carvedilol, represent a significant advancement in managing cardiovascular conditions. Unlike conventional β-blockers, which can induce peripheral vasoconstriction, third-generation drugs block α1 adrenoceptors. This promotes vasodilation through several mechanisms, such as increased nitric oxide production, inhibition of calcium ion entry, opening of potassium ion channels, and antioxidant action. Labetalol, for instance, is...
1.4K
Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers01:27

Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers

1.9K
β-receptor blockers significantly impact the cardiovascular system by counteracting catecholamine-induced sympathetic responses. These medications decrease heart rate, contractility, and cardiac output, potentially leading to cardiac depression, life-threatening bradycardia, and death. Therapeutically, β-blockers function as mild antihypertensives and are utilized in treating angina pectoris and cardiac arrhythmias. However, nonselective β-blockers inhibit β2-receptors in...
1.9K
Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

424
Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
424

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A simple, low-cost bubble CPAP system for use in the delivery room and during transport to the NICU for infants with respiratory distress: A feasibility study.

Journal of neonatal-perinatal medicine·2026
Same author

Assessing the real-world effects of prophylactic hydrocortisone in the Canadian Neonatal Network: A cohort study.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Predicting bronchopulmonary dysplasia is complicated (as it should be): toward a framework for integrating physiological data.

Pediatric research·2026
Same author

Variation in Stabilization and Resuscitation Practices at Birth of Preterm Infants Among 12 National or Regional Neonatal Networks.

Acta paediatrica (Oslo, Norway : 1992)·2026
Same author

Respiratory trajectories of infants born before 26 weeks of gestation from birth to discharge: an exploratory analysis of a randomised controlled trial.

The Lancet. Child & adolescent health·2026
Same author

Clinical study: Cardiovascular outcomes after a 14-week exercise intervention in young adults born preterm.

Pediatric research·2026

Related Experiment Video

Updated: Mar 29, 2026

Intratracheal Instillation of Stem Cells in Term Neonatal Rats
04:27

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Published on: May 4, 2020

6.2K

Postnatal Steroids in Preterm Infants: A Narrative Review Series-Part 2: Cardiovascular Impacts.

Phoenix Plessas-Azurduy1, Anie Lapointe2, Punnanee Wutthigate3

  • 1Division of Clinical & Translational Research, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3A 0G4, Canada.

Children (Basel, Switzerland)
|March 28, 2026
PubMed
Summary

Postnatal corticosteroids for preterm infants impact cardiovascular health, affecting ductal closure, blood pressure, and heart structure. Monitoring tools like echocardiography can help personalize steroid use and minimize harm.

Keywords:
autonomic regulationcardiovascular physiologycorticosteroidsextremely preterm infantsheart rate variabilityindividualized steroid therapymyocardial remodelingpatent ductus arteriosuspulmonary hypertensiontargeted neonatal echocardiography

More Related Videos

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

12.0K
Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System
07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

12.5K

Related Experiment Videos

Last Updated: Mar 29, 2026

Intratracheal Instillation of Stem Cells in Term Neonatal Rats
04:27

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Published on: May 4, 2020

6.2K
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

12.0K
Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System
07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

12.5K

Area of Science:

  • Neonatal Physiology
  • Pharmacology
  • Cardiovascular Medicine

Background:

  • Postnatal corticosteroids are common for extremely preterm infants to aid respiratory management.
  • Their complex and underexplored effects on the immature cardiovascular system necessitate further investigation.

Purpose of the Study:

  • To review the cardiovascular consequences of systemic corticosteroid therapy in preterm neonates.
  • To examine corticosteroid influence on ductal closure, vascular resistance, myocardial remodeling, and autonomic regulation.

Main Methods:

  • Narrative review synthesizing mechanistic insights and clinical evidence.
  • Analysis of corticosteroid interactions with early postnatal hemodynamic transition and vascular development.
  • Discussion of diagnostic tools for monitoring cardiovascular effects.

Main Results:

  • Corticosteroids may influence ductal patency, systemic and pulmonary vascular resistance, and myocardial remodeling.
  • Potential for corticosteroids to contribute to reactive myocardial hypertrophy, systemic hypertension, and pulmonary hypertension.
  • Emerging tools like targeted neonatal echocardiography (TnECHO), ECG, heart rate variability, and biomarkers can aid monitoring.

Conclusions:

  • A nuanced understanding of corticosteroid effects on the developing cardiovascular system is crucial.
  • Integrating cardiovascular monitoring into routine care is essential for optimizing benefits and minimizing harm.
  • This review supports a framework for individualized, physiology-driven steroid use in preterm infants.