Global Stakeholder Perspectives on Real-World Data and Evidence in Health Technology Assessment: An Exploratory...

Area of Science:

• Health Technology Assessment
• Real-World Data (RWD)
• Real-World Evidence (RWE)

Background:

• Health Technology Assessment (HTA) increasingly considers real-world data (RWD) and real-world evidence (RWE).
• Understanding stakeholder perceptions on RWD/RWE in HTA is crucial for its effective integration.

Purpose of the Study:

• To capture an international, multi-stakeholder snapshot of perceptions on RWD/RWE in HTA.
• To identify perceived opportunities, barriers, and enabling conditions for RWD/RWE use in HTA.

Main Methods:

• An expert-validated, 21-item questionnaire was distributed to diverse HTA stakeholders.
• Descriptive statistics were used to analyze the preliminary, exploratory data.

Main Results:

• Preliminary support exists for integrating RWD/RWE into HTA.
• RWD/RWE are valued for complementing clinical trials, especially for rare diseases and cancer.
• Key challenges include data quality, bias, and regulatory hurdles; standardization and collaboration are vital.

Conclusions:

• RWD/RWE can enhance HTA for better decision-making and personalized care.
• Addressing data quality, methodology, and trust through standardization and collaboration is essential for implementation.