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Multi-Target Photoprotection by Taxifolin Against UVB-Induced Keratinocyte Injury Through UVB Filtration, ROS

Fangfang Chen1,2, Yihan Cai1, Jinxiong Wu1

  • 1The School of Public Health and Medical Technology, Xiamen Medical College, Xiamen 361023, China.

Biomolecules
|March 28, 2026
PubMed
Summary

Taxifolin, a natural flavonoid, protects skin cells from UV damage by scavenging reactive oxygen species and modulating cell signaling pathways. This study reveals its multi-target photoprotective mechanisms against UVB injury.

Keywords:
JNK/p38 MAPKROSUVBmulti-omicstaxifolin

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Area of Science:

  • Dermatology
  • Biochemistry
  • Molecular Biology

Background:

  • Natural flavonoids like taxifolin offer cytoprotection against oxidative stress.
  • Ultraviolet B (UVB) radiation causes significant skin damage through oxidative stress and apoptosis.
  • Understanding the molecular mechanisms of photoprotection is crucial for developing effective skincare strategies.

Purpose of the Study:

  • To evaluate the photoprotective effects of taxifolin against UVB-induced injury in HaCaT cells.
  • To elucidate the underlying molecular mechanisms, including antioxidant and signaling pathway modulation.
  • To identify key molecular mediators involved in taxifolin's protective action.

Main Methods:

  • Cell viability and apoptosis assays (MTT, fluorescence staining, flow cytometry).
  • In vitro antioxidant capacity and UVB absorption spectrum analysis.
  • Integrative transcriptomic and proteomic analyses.
  • Western blot analysis for key signaling proteins (JNK/p38 MAPK).

Main Results:

  • Taxifolin demonstrated antioxidant capacity and UVB absorption, acting as a chemical sunscreen.
  • It reduced UVB-induced reactive oxygen species (ROS) and attenuated JNK/p38 MAPK activation.
  • Multi-omics data showed taxifolin alleviated cell cycle arrest and promoted pro-survival gene expression.
  • Taxifolin significantly suppressed apoptosis and enhanced cell survival.

Conclusions:

  • Taxifolin provides multi-target photoprotection against UVB injury through chemical filtration, ROS scavenging, and signaling modulation.
  • It breaks the ROS-MAPK vicious cycle and activates pro-survival pathways.
  • Taxifolin represents a promising natural compound for photoprotection and skin health.