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Related Concept Videos

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Related Experiment Video

Updated: Mar 29, 2026

Isolation and Propagation of Circulating Tumor Cells from a Mouse Cancer Model
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Circulating Tumor Cells: Isolation, Preclinical Models, and Clinical Applications for Personalized Cancer Therapy.

Luisana Sisca1,2, Mariam Grazia Polito1,3, Michele Iuliani1

  • 1Department of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy.

Biomolecules
|March 28, 2026
PubMed
Summary

Circulating tumor cells (CTCs) offer a minimally invasive view into cancer. Advanced technologies now enable detailed analysis of CTCs and the creation of patient-specific models for personalized cancer therapy.

Keywords:
circulating tumor cellsfunctional drug testingliquid biopsypersonalized cancer therapypreclinical modelstumor heterogeneity

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Area of Science:

  • Oncology
  • Biotechnology

Background:

  • Circulating tumor cells (CTCs) are crucial for understanding tumor biology and evolution.
  • Technological advancements have enhanced the isolation and analysis of viable CTCs.

Purpose of the Study:

  • To review current technologies for CTC isolation and characterization.
  • To discuss the translational impact of CTC-derived models in precision oncology.

Main Methods:

  • Microfluidic platforms
  • Immunomagnetic enrichment
  • Aptamer-based capture
  • Nanostructured interfaces

Main Results:

  • Improved efficiency and fidelity of CTC recovery.
  • Development of CTC-derived preclinical models (xenografts, organoids).
  • Enabling patient-specific drug-sensitivity testing.

Conclusions:

  • CTC-derived models recapitulate tumor heterogeneity.
  • Integration of multi-omics and AI can accelerate clinical application of CTC-guided therapy.