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Updated: Mar 29, 2026

High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability
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Mitochondrial Stress in Helicobacter pylori Infection and Associated Malignancies: A Review

Viola Varga1, András Gelley2, Eva Margittai1

  • 1Institute of Clinical Pathophysiology, Semmelweis University, 1085 Budapest, Hungary.

Antioxidants (Basel, Switzerland)
|March 28, 2026
PubMed

Insights

Helicobacter pylori infection is linked to gastric cancer and MALT lymphoma. This review explores how mitochondrial stress contributes to these H. pylori-associated cancers.

Area of Science:

  • Oncology
  • Microbiology
  • Cell Biology

Background:

  • Helicobacter pylori (H. pylori) infection is a prevalent global health issue.
  • H. pylori is a known risk factor for gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma.
  • Mitochondrial alterations in these cancers are under-researched.

Purpose of the Study:

  • To review the role of mitochondrial stress in H. pylori infection.
  • To examine mitochondrial alterations in H. pylori-associated gastric cancer.
  • To explore mitochondrial dysfunction in MALT lymphoma.

Main Methods:

  • Literature review of studies on H. pylori infection.
  • Analysis of research on mitochondrial function in gastric cancer.
  • Review of studies investigating MALT lymphoma and mitochondrial pathways.

Main Results:

  • Mitochondria are crucial for cellular homeostasis and play a role in carcinogenesis.
  • H. pylori infection can induce mitochondrial stress.
  • Mitochondrial alterations are implicated in the progression of H. pylori-associated gastric cancer and MALT lymphoma.

Conclusions:

  • Mitochondrial stress is a significant factor in H. pylori-associated malignancies.
  • Understanding mitochondrial alterations may offer new therapeutic targets.
  • Further research into mitochondrial pathways is warranted for gastric cancer and MALT lymphoma.
Keywords:
Helicobacter pyloriMALT lymphomagastric cancermitochondrial stress

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