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Updated: Mar 29, 2026

State of the Art Cranial Ultrasound Imaging in Neonates
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The Safety of Ultrasound Contrast Agents in Children

Ruiqi Wang1, Juan Wang2, Hongli Zhai1

  • 1Department of Ultrasound, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing 400014, China.

Diagnostics (Basel, Switzerland)
|March 28, 2026
PubMed

Insights

Contrast-enhanced ultrasound (CEUS) is safe for pediatric patients, with a low incidence of mild adverse events. This study found CEUS well-tolerated in children, with no severe reactions observed.

Area of Science:

  • Pediatric Imaging
  • Medical Ultrasound
  • Radiology

Background:

  • Assessing the safety of contrast-enhanced ultrasound (CEUS) in pediatric populations is crucial for its clinical application.
  • Previous studies have indicated CEUS safety, but data specific to large pediatric cohorts are continually being gathered.

Purpose of the Study:

  • To retrospectively analyze the safety profile of contrast-enhanced ultrasound (CEUS) in pediatric patients.
  • To determine the incidence, severity, and types of adverse reactions associated with CEUS in children.

Main Methods:

  • A retrospective analysis of pediatric patients undergoing intravenous CEUS examinations between 2019 and 2025.
  • Classification of adverse reactions by severity (mild, moderate, severe), pharmacological type (Type A, Type B), and onset timing (immediate, delayed).

Main Results:

  • 1604 pediatric patients underwent 1924 CEUS examinations, with an overall adverse reaction incidence of 0.436%.
  • Seven patients experienced adverse reactions, predominantly mild (85.71%) and moderate (14.29%), with no severe events.
  • All recorded adverse reactions were immediate onset, with 75% classified as Type B and 25% as Type A.

Conclusions:

  • Contrast-enhanced ultrasound (CEUS) demonstrates a favorable safety profile in the pediatric population.
  • The low incidence of mild adverse reactions suggests CEUS is a safe imaging modality for children.
  • No serious adverse events were reported, supporting the continued use of CEUS in pediatric practice.

Keywords:
adverse reactionschildrencontrast-enhanced ultrasoundsecurityultrasound contrast agent

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