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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Related Experiment Video

Updated: Mar 29, 2026

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
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APSified Peripapillary Vessel Density in Glaucoma Suspects and Open-Angle Glaucoma.

Michael Moritz1, Julia Schottenhamml1, Marius Muenk1

  • 1Department of Ophthalmology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.

Diagnostics (Basel, Switzerland)
|March 28, 2026
PubMed
Summary

Optical coherence tomography-angiography (OCT-A) reveals decreased peripapillary vessel density (VD) in glaucoma patients compared to healthy individuals. This finding suggests OCT-A may aid in monitoring glaucoma progression.

Keywords:
OCT-AOHTglaucomaglaucoma suspectsvessel density

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Vascular dysregulation is implicated in glaucoma pathogenesis.
  • Optical coherence tomography-angiography (OCT-A) offers non-invasive visualization of the capillary system.
  • Evaluating peripapillary vessel density (VD) is crucial for understanding glaucoma.

Purpose of the Study:

  • To assess APSified-BMO-based peripapillary vessel density (VD) in ocular hypertension (OHT) and open-angle glaucoma (OAG) patients versus healthy controls.
  • To investigate the utility of OCT-A in differentiating glaucoma stages.
  • To correlate peripapillary VD with glaucoma severity and progression.

Main Methods:

  • Included 180 eyes from 115 patients (OHT, pre-perimetric OAG, primary OAG, secondary OAG, healthy controls).
  • Utilized OCT-A to visualize and quantify APSified-BMO-based peripapillary VD using the Erlangen Angio Tool.
  • Performed measurements of RNFL, INL, RGC layer, and BMO-MRW.

Main Results:

  • Mean peripapillary VD showed a significant correlation with age.
  • OAG patients exhibited significantly lower peripapillary VD compared to healthy eyes and OHT patients, after accounting for age.
  • Significant differences in VD were found between controls and POAG/SOAG, and between OHT and POAG patients.

Conclusions:

  • Peripapillary vessel density is significantly decreased in glaucoma patients compared to controls.
  • OCT-A-derived peripapillary VD may serve as a valuable biomarker for monitoring glaucoma progression.
  • Further research can explore the role of VD in early glaucoma detection and management.