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Bioactive Peptides-Probiotics Interactions: Implications for Microbial Function and Human Health.

Yue Fan1, Qingping Wu2,3, Lanyan Huang2

  • 1School of Food Science and Engineering, Shaanxi University of Science & Technology, Xi'an 710021, China.

Foods (Basel, Switzerland)
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Summary
This summary is machine-generated.

This review explores how food-derived bioactive peptides (BPs) interact with probiotic lactic acid bacteria (LAB). It highlights peptide transport mechanisms and their impact on microbial growth and metabolism, offering insights into functional food development.

Keywords:
bioactive peptides (BPs)functional foodsgut microbiotahealth promotionlactic acid bacteria (LAB)probiotics

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Area of Science:

  • Food Science and Nutrition
  • Microbiology
  • Gastrointestinal Health

Background:

  • Bioactive peptides (BPs) and probiotics, especially lactic acid bacteria (LAB), are key in functional food research.
  • LAB possess efficient peptide transport systems (e.g., Opp, Dpp) crucial for gut microbiota metabolism.
  • Understanding BP-LAB interactions is vital for developing novel functional foods and improving gut health.

Purpose of the Study:

  • To review current knowledge on food-derived bioactive peptides (BPs) and their interactions with probiotic lactic acid bacteria (LAB).
  • To focus on the mechanisms of peptide transport and utilization by LAB, including oligopeptide (Opp) and di-/tripeptide (Dpp) permease systems.
  • To discuss sources, production, analytical methods, and the impact of BPs on LAB growth and metabolism.

Main Methods:

  • Literature review summarizing existing research on bioactive peptides and probiotics.
  • Focus on mechanisms of peptide transport and utilization (Opp, Dpp systems) in LAB.
  • Analysis of experimental evidence regarding peptide-supported microbial growth and metabolic responses.

Main Results:

  • Food-derived bioactive peptides significantly influence LAB growth and metabolic activities.
  • Oligopeptide permease (Opp) and di-/tripeptide permease (Dpp) systems are primary mechanisms for BP uptake in LAB.
  • Most evidence comes from in vitro studies, showing microbial responses rather than direct host effects.

Conclusions:

  • Bioactive peptides play a crucial role in modulating LAB metabolism and function.
  • Further research is needed to elucidate host-level effects and optimize nitrogen utilization by LAB through BPs.
  • This review provides a mechanistic basis for peptide-probiotic interactions in LAB for functional food applications.