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ARHGDIB Modulates Subcutaneous Fat Deposition in Ducks
Mingyu Wang1, Hao Zheng1, Xing Chen2
1Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China.
Animals : an Open Access Journal From MDPI
|March 28, 2026
Summary
ARHGDIB negatively regulates fat deposition in ducks. Its suppression enhances adipogenesis, offering a target for improving meat quality and feed efficiency through precision breeding.
Area of Science:
- Animal Science
- Molecular Biology
- Genetics
Background:
- Subcutaneous fat deposition is crucial for duck meat quality and feed efficiency.
- The Rho GTPase regulator ARHGDIB's role in poultry adipogenesis is unknown.
Purpose of the Study:
- To investigate the function of ARHGDIB in duck subcutaneous fat deposition.
- To explore ARHGDIB as a potential target for enhancing meat quality and feed efficiency.
Main Methods:
- Growth and fat deposition monitored in ducks (30-70 days).
- Adipose tissue transcriptomics performed.
- An in vitro duck preadipocyte model used to assess ARHGDIB function via siRNA knockdown, Oil Red O staining, and RNA-seq.
Main Results:
- ARHGDIB expression decreased during adipocyte differentiation.
- ARHGDIB knockdown significantly increased lipid accumulation.
- Knockdown altered expression of 1681 genes involved in key metabolic and signaling pathways.
Conclusions:
- ARHGDIB acts as a negative regulator of duck adipogenesis.
- ARHGDIB suppresses adipocyte differentiation and modulates metabolic-inflammatory networks.
- ARHGDIB presents a potential target for precision breeding to improve duck production traits.
