Related Experiment Video
Updated: Mar 29, 2026
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
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Characterizing Race-Based Differences in Antisynthetase Syndrome Interstitial Lung Disease.
Faye Pais1,2, Caroline M Cook3, Stephen Simeone1
1Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610, USA.
Biomedicines
|March 28, 2026
Summary
Black patients with antisynthetase syndrome-interstitial lung disease (ASyS-ILD) are diagnosed younger and have reduced lung function and increased traction bronchiectasis compared to White patients. Mortality rates were similar between racial groups.
Area of Science:
- Pulmonology
- Rheumatology
- Immunology
Background:
- Interstitial lung disease (ILD) is a severe complication of antisynthetase syndrome (ASyS).
- Limited data exists on racial disparities in ASyS-ILD presentation and outcomes.
- This study addresses the gap by comparing Black and White patients with ASyS-ILD.
Purpose of the Study:
- To compare clinical manifestations, pulmonary function, and outcomes between Black and White patients diagnosed with ASyS-ILD.
- To identify potential racial differences in the disease course and associated comorbidities.
Main Methods:
- Retrospective analysis of electronic health records from 2010-2020.
- Inclusion criteria: diagnosis of ILD and positive antisynthetase antibodies.
- Comparison of demographics, comorbidities, clinical features, pulmonary function, imaging, and outcomes between 34 Black and 32 White patients.
Main Results:
- Black patients were younger at diagnosis (49.1 vs. 55.1 years) and exhibited reduced pulmonary function.
- Higher prevalence of traction bronchiectasis (96.6% vs. 73.1%) and obstructive sleep apnea in Black patients.
- No significant differences observed in hospitalization rates, ICU admissions, mortality, or need for lung transplantation between racial groups.
Conclusions:
- Black patients with ASyS-ILD present at a younger age with diminished lung function and more traction bronchiectasis.
- Obstructive sleep apnea is more prevalent in Black patients, irrespective of BMI.
- Further prospective research is essential to understand long-term, race-based differences in ASyS-ILD morbidity and mortality.
