Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

IOA-244, a novel p110δ PI3K inhibitor, blocks breast tumour progression on either mono- or combined-therapy.

Cell death discovery·2026

Same author

Author Correction: Albumin orchestrates a natural host defence mechanism against mucormycosis.

Nature·2026

Same author

NGF promotes, in an autocrine-paracrine manner, metabolic and anti-inflammatory pathways in human and mouse adipocytes.

The Journal of clinical endocrinology and metabolism·2026

Same author

Albumin orchestrates a natural host defence mechanism against mucormycosis.

Nature·2026

Same author

Pharmacological Characterization of the Novel CRF1 Receptor Antagonist, Thiazolo[4,5-d] Pyrimidine Analog, M43.

Biomolecules·2025

Same author

Hypertriglyceridemia impairs HDL functionality, promotes macrophage metabolic activation and exacerbates antigen-induced rheumatoid arthritis in mice which can be reversed by fenofibrate treatment.

Biochimica et biophysica acta. Molecular and cell biology of lipids·2025

Search research articles

Related Experiment Video

Updated: Mar 29, 2026

Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation

Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation

Published on: January 25, 2016

Heat Shock Protein 70 Deficient Mice Exhibit Reduced Psoriasis-like Skin Inflammation.

Aikaterini Kalantidou¹, Maria Kostakou¹, Michail Deiktakis¹

¹Department of Clinical Chemistry, Medical School, University of Crete, 70013 Heraklion, Crete, Greece.

|March 28, 2026

Summary

Heat shock protein 70 (HSP70) deficiency significantly reduced psoriasis-like skin inflammation in a mouse model. This suggests HSP70 plays a key role in psoriasis pathogenesis and could be a potential therapeutic target.

Keywords:

HSP70 heat shock proteins psoriasis

More Related Videos

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

Related Experiment Videos

Last Updated: Mar 29, 2026

Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation

Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation

Published on: January 25, 2016

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

Area of Science:

Immunology
Dermatology
Molecular Biology

Background:

Psoriasis is a chronic inflammatory skin disease affecting 1-2% of Caucasians.
Its underlying mechanisms are not fully understood, though heat shock proteins (HSPs) are implicated.
Previous research on HSPs in psoriasis is inconclusive.

Purpose of the Study:

To investigate the role of heat shock protein 70 (HSP70) deficiency in psoriasis pathogenesis.
To use an in vivo mouse model to study the effects of Hsp70 gene absence.

Main Methods:

Male mice, either normal (Hsp70+/+) or deficient (Hsp70-/-), were used.
Psoriasis was induced using imiquimod cream over 7 days.
Skin inflammation severity was assessed using PASI scores, histology, and flow cytometry.

Main Results:

Hsp70 deficiency led to reduced skin inflammation and histological abnormalities.
PASI scores were significantly lower in Hsp70-deficient mice.
Flow cytometry showed decreased monocyte and increased neutrophil infiltration in Hsp70-/- mice, with altered HSP60 and HSP90 expression.

Conclusions:

HSP70 plays a significant regulatory role in psoriatic inflammation.
HSP70 deficiency ameliorates psoriasis-like symptoms in mice.
HSP70 emerges as a potential therapeutic target for psoriasis treatment.