Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

568
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
568
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

3.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.4K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

751
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
751
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

445
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
445
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

319
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
319
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

849
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
849

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oxidative Stress Biomarkers and Systemic Inflammatory Indices in Metabolic Dysfunction-Associated Steatotic Liver Disease with Type 2 Diabetes Mellitus: A Comparative and Longitudinal Analysis.

International journal of molecular sciences·2026
Same author

Paraneoplastic Endocrine Changes in Gastrointestinal Tumors: A Clinical and Mechanistic Review.

International journal of molecular sciences·2026
Same author

Sedation as an Immunomodulator of Inflammatory Responses in the Lung-Brain Axis of ARDS.

International journal of molecular sciences·2026
Same author

Mechanisms Linking Recurrent Bacterial Urinary Tract Infections to Chronic Kidney Disease Progression.

International journal of molecular sciences·2026
Same author

True Preoperative Liquid Fasting in Romania-A Secondary Analysis of the Thirst Study.

Nutrients·2026
Same author

Evaluation of oxidative stress in acute pancreatitis.

Frontiers in immunology·2026

Related Experiment Video

Updated: Mar 29, 2026

Real-time Pressure-volume Analysis of Acute Myocardial Infarction in Mice
07:28

Real-time Pressure-volume Analysis of Acute Myocardial Infarction in Mice

Published on: July 2, 2018

9.7K

Association Between Myocardial Dysfunction and Septic Shock.

Vlad Pădureanu1, Daniel Cosmin Caragea2, Denisa Floriana Vasilica Pîrșcoveanu3

  • 1Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

International Journal of Molecular Sciences
|March 28, 2026
PubMed
Summary
This summary is machine-generated.

Sepsis-induced cardiac dysfunction significantly increases mortality. Mitochondrial dysfunction is a key factor, and current treatments lack efficacy, highlighting the need for targeted therapies to improve patient outcomes.

Keywords:
cardiomyopathymyocardial dysfunctionsepsisseptic shock

More Related Videos

Endotoxin Activity Assay for the Detection of Whole Blood Endotoxemia in Critically Ill Patients
06:28

Endotoxin Activity Assay for the Detection of Whole Blood Endotoxemia in Critically Ill Patients

Published on: June 24, 2019

10.0K
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

20.3K

Related Experiment Videos

Last Updated: Mar 29, 2026

Real-time Pressure-volume Analysis of Acute Myocardial Infarction in Mice
07:28

Real-time Pressure-volume Analysis of Acute Myocardial Infarction in Mice

Published on: July 2, 2018

9.7K
Endotoxin Activity Assay for the Detection of Whole Blood Endotoxemia in Critically Ill Patients
06:28

Endotoxin Activity Assay for the Detection of Whole Blood Endotoxemia in Critically Ill Patients

Published on: June 24, 2019

10.0K
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

20.3K

Area of Science:

  • Cardiology
  • Sepsis Research
  • Mitochondrial Biology

Background:

  • Sepsis-induced cardiac dysfunction is strongly linked to increased mortality.
  • Mitochondrial dysfunction plays a critical role in the pathophysiology of sepsis-induced myocardial dysfunction.
  • Current therapeutic strategies have not significantly improved patient outcomes.

Purpose of the Study:

  • To outline current knowledge on the pathophysiological mechanisms of sepsis-induced cardiac dysfunction.
  • To review the impact of monitoring techniques on sepsis-induced myocardial dysfunction.
  • To discuss current treatment strategies and the need for novel approaches.

Main Methods:

  • Review of existing literature on sepsis-induced cardiac dysfunction.
  • Analysis of pathophysiological mechanisms, including mitochondrial dysfunction.
  • Evaluation of current monitoring methods (clinical assessment, hemodynamics, echocardiography, biomarkers).

Main Results:

  • Mitochondrial dysfunction is a central mechanism in sepsis-induced cardiac dysfunction.
  • Existing treatments offer limited improvement in patient outcomes.
  • Effective monitoring involves a combination of clinical, hemodynamic, and imaging techniques.

Conclusions:

  • Targeting specific pathways of cardiac dysfunction in sepsis is crucial for developing novel treatments.
  • Improved monitoring strategies aid in timely treatment optimization.
  • Further research is needed for targeted therapies beyond general sepsis management.