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Updated: Mar 29, 2026

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

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Published on: August 9, 2019

Recent Advances in Aptamer-Based Applications in Cardiology.

Aleksandra Kosinova^1,2, Tatiana Zamay^1,3, Yury Glazyrin^1,3

¹Laboratory for Digital Controlled Drugs and Theranostics, Federal Research Center "Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Science", 660036 Krasnoyarsk, Russia.

International Journal of Molecular Sciences

|March 28, 2026

Summary

Aptamers offer advanced diagnostics and targeted therapies for cardiovascular diseases (CVDs). These DNA/RNA molecules enable sensitive biomarker detection and precise drug delivery, revolutionizing CVD intervention.

Keywords:

aptamers cardiovascular diseases drug delivery nanomaterials thrombosis

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Area of Science:

Biochemistry
Molecular Biology
Cardiology

Background:

Cardiovascular diseases (CVDs) represent a significant global health burden.
Current diagnostic and therapeutic strategies for CVDs have limitations in sensitivity and specificity.
Aptamers, as novel oligonucleotide tools, show promise in addressing these limitations.

Purpose of the Study:

To review the emerging role of aptamers in cardiology.
To highlight aptamer applications in CVD diagnostics, therapeutics, and theranostics.
To discuss the integration of aptamers with nanomaterials for enhanced platforms.

Main Methods:

Literature review of aptamer applications in cardiovascular medicine.
Analysis of aptamer-based biosensors for cardiac biomarkers.
Evaluation of aptamer-based anticoagulation and drug delivery systems.
Assessment of aptamer-nanomaterial conjugates.

Main Results:

Aptamers enable highly sensitive biosensors for cardiac biomarkers, facilitating early detection and point-of-care testing.
Aptamers provide targeted, controllable, and reversible anticoagulation therapies.
Aptamers function as precision delivery vehicles for therapeutic agents to cardiomyocytes.
Integration with nanomaterials enhances aptamer-based biosensing and drug delivery platforms.

Conclusions:

Aptamer technology holds significant potential for personalized cardiovascular disease interventions.
Ongoing clinical trials demonstrate the clinical viability of aptamer-based diagnostics and therapeutics.
Further research into aptamer stability and immunogenicity is crucial for clinical translation.