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Updated: Mar 29, 2026

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
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Autotaxin Induces S1P/S1PR1 Signaling to Affect Th17/Treg Cell Balance and Exacerbate Intestinal Inflammation in

Siqi Xiao1,2, Kaixin Peng1,2, Congxin Li1,2

  • 1Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

International Journal of Molecular Sciences
|March 28, 2026
PubMed
Summary

Autotaxin (ATX) drives ulcerative colitis (UC) by increasing sphingosine-1-phosphate (S1P) and its receptor S1PR1, disrupting T helper 17 (Th17) and regulatory T (Treg) cell balance, leading to gut inflammation.

Keywords:
Th17/Treg cell balanceautotaxincolitisintestinal immunitysphingosine-1-phosphate

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