Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Evolutionary Relationships through Genome Comparisons

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

DNA Yield and Degradation in Skeletal Remains from Two Slovenian Second World War Mass Graves: A Comparative Study of Different Bone Types.

Genes·2026

Same author

Isotopic Values of Prenatal Development: δ<sup>13</sup>C and δ<sup>15</sup>N Variation in Early-Formed Human Tissues.

American journal of biological anthropology·2026

Same author

Autosomal STR Markers for Forensic Genetics: Applications, Challenges, and Future Directions.

Genes·2026

Same author

Advances in Nondestructive DNA Extraction from Teeth for Human Identification.

Genes·2026

Same author

Analysis of Human Degraded DNA in Forensic Genetics.

Genes·2025

Same author

Comparison of classic Sanger and next generation sequencing mitotypes of second world war victims from Konfin I mass grave.

International journal of legal medicine·2025

Search research articles

Related Experiment Video

Updated: Mar 29, 2026

Optimized Bone Sampling Protocols for the Retrieval of Ancient DNA from Archaeological Remains

Optimized Bone Sampling Protocols for the Retrieval of Ancient DNA from Archaeological Remains

Published on: November 30, 2021

Integrative Forensic Genetics, Biochemical, and Histological Methods for Reconstructing Biological Profiles from Aged

Irena Zupanič Pajnič¹, Tamara Leskovar²

¹Institute of Forensic Medicine, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia.

|March 28, 2026

Summary

Reconstructing biological profiles from degraded skeletal remains is challenging. Combining genomic, isotopic, epigenetic, proteomic, and histological methods offers a powerful, integrative approach for forensic and bioarchaeological identification.

Keywords:

FIGG SNP genotyping aged skeletal remains biological sex forensic DNA intelligence human identification methylation-based age prediction multi-isotope analysis tooth cementum annulation

More Related Videos

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic ‘Touch DNA’ Evidence

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic ‘Touch DNA’ Evidence

Published on: March 9, 2015

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Related Experiment Videos

Last Updated: Mar 29, 2026

Optimized Bone Sampling Protocols for the Retrieval of Ancient DNA from Archaeological Remains

Optimized Bone Sampling Protocols for the Retrieval of Ancient DNA from Archaeological Remains

Published on: November 30, 2021

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic ‘Touch DNA’ Evidence

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic ‘Touch DNA’ Evidence

Published on: March 9, 2015

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Area of Science:

Forensic Anthropology
Bioarchaeology
Molecular Anthropology

Background:

Reconstructing biological profiles from degraded human remains is a significant challenge in forensic and bioarchaeological studies.
Conventional identification methods often fail with aged or compromised skeletal samples.

Purpose of the Study:

To review and synthesize current integrative approaches for reconstructing biological profiles from degraded human skeletal remains.
To highlight the value of combining diverse analytical techniques for enhanced identification and life-history reconstruction.

Main Methods:

Genomic analyses (including next-generation sequencing - NGS)
Stable isotope investigations
Epigenetic age estimation
Proteomic sex determination
Histological techniques (e.g., Tooth Cementum Annulation - TCA)

Main Results:

Integrative approaches combining molecular, biochemical, and histological data significantly enhance the ability to infer sex, ancestry, kinship, age, diet, mobility, and geographic origin.
NGS provides robust genetic inference from highly degraded samples.
Stable isotopes reveal dietary patterns and mobility, while DNA methylation improves age estimation accuracy.

Conclusions:

A multidisciplinary perspective, integrating complementary datasets, is crucial for robust biological profile reconstruction.
Combining molecular, biochemical, and histological evidence offers a more nuanced understanding of past individuals in forensic and archaeological contexts.