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Mobile Laminar Airflow for Intravitreal Injections: Reducing Microbial Load at the Instrument Field.

Vittoria Satriani1, Giovanni Boccia1,2,3, Biagio Santella1

  • 1Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Salerno, Italy.

Journal of Clinical Medicine
|March 28, 2026
PubMed
Summary
This summary is machine-generated.

Mobile laminar airflow units significantly reduce airborne microbes during intravitreal injections (IVIs) in outpatient clinics. This technology maintains an ultraclean instrument field, enhancing patient safety in high-volume settings.

Keywords:
airborne contaminationendophthalmitis preventionenvironmental monitoringintravitreal injectionlaminar airflow

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Area of Science:

  • Ophthalmology
  • Infectious Disease Control
  • Medical Engineering

Background:

  • Intravitreal injections (IVIs) are common outpatient procedures.
  • Ensuring operating-theatre-level environmental safety for IVIs is a growing concern.
  • Limited microbiological data exists for mobile laminar airflow (LAF) units in real-world IVI clinics.

Purpose of the Study:

  • To evaluate the microbiological effectiveness of a mobile laminar airflow (LAF) device in an outpatient intravitreal injection (IVI) setting.
  • To assess airborne and surface microbial contamination during IVI procedures with and without LAF.
  • To determine if the mobile LAF unit can maintain an ultraclean instrument field.

Main Methods:

  • Environmental monitoring of airborne microbial contamination using SAS Super 100 impactors.
  • Measurement of airborne microbes at two locations: room air and within the LAF field.
  • Assessment of surface contamination on instrument drapes using contact plates.
  • Analysis of data using two-way repeated-measures ANOVA with post hoc comparisons.

Main Results:

  • Mobile LAF operation reduced mean airborne microbial load by 87.9% compared to room air (p < 0.01).
  • No significant difference in airborne counts between locations when LAF was off.
  • No obligate pathogens detected; airborne microbes were mainly commensals.
  • Zero colony-forming units (CFUs) detected on all instrument drape surface samples.

Conclusions:

  • The mobile LAF device effectively creates and maintains a stable ultraclean microenvironment at the instrument field.
  • LAF is a valuable adjunct to standard aseptic measures in high-throughput outpatient IVI clinics.
  • The covering drape did not require changing during the session when using the mobile LAF unit.