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Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
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Related Experiment Video

Updated: Mar 29, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

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Lung Cancer Risk Factors Beyond Smoking in Ethiopia: A Multicenter Matched Case-Control Study.

Nathan Estifanos1,2, Gudina Egata1, Adamu Addissie1

  • 1School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa P.O. Box 9086, Ethiopia.

Cancers
|March 28, 2026
PubMed
Summary

Lung cancer in Ethiopia is linked to factors beyond smoking, including solid-fuel use and diet. Public health efforts should address these local risks for better prevention and early detection.

Keywords:
Ethiopiacase–control studylung cancerrisk factors

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Last Updated: Mar 29, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

918

Area of Science:

  • Environmental Health
  • Epidemiology
  • Oncology

Background:

  • Smoking is a primary lung cancer cause globally, but not in Ethiopia, where local risk factors are significant.
  • Limited evidence exists for lung cancer prevention and early detection in resource-limited settings.

Purpose of the Study:

  • To identify lung cancer risk factors in Ethiopia beyond smoking.
  • To inform gender-sensitive public health interventions for lung cancer prevention and early detection.

Main Methods:

  • A multicenter matched case-control study with 351 lung cancer cases and 702 controls.
  • Variables selected using directed acyclic graphs.
  • Multivariable hierarchical conditional logistic regression to identify risk factors.

Main Results:

  • Lung cancer associated with low education, wealth, solid-fuel use, occupational exposure, low physical activity, specific diets, secondhand smoke (SHS), prior tuberculosis, and family cancer history.
  • Consistent associations found across sexes, but exposure patterns differed: males more exposed to smoking, occupational risks, meat diets; females to SHS, solid fuels, processed foods.
  • Identified key risk factors beyond smoking in the Ethiopian population.

Conclusions:

  • Lung cancer in Ethiopia is multifactorial, with significant non-smoking-related risks.
  • Targeting locally relevant factors like solid-fuel use and dietary patterns is crucial.
  • Gender-sensitive interventions are essential for effective lung cancer control in Ethiopia.