Multicenter Assessment of Postoperative Mastocheck^® Dynamics Following Curative Breast Cancer Surgery

Area of Science:

• Oncology
• Biomarker Research
• Clinical Diagnostics

Background:

• Previous studies indicated a drop in Mastocheck® values post-breast cancer surgery.
• The reproducibility of this postoperative decline was not yet established across independent cohorts.

Purpose of the Study:

• To assess the reproducibility of postoperative decreases in Mastocheck® values.
• To evaluate these changes in two independent clinical cohorts with different assessment designs.

Main Methods:

• Two independent cohorts (CHA Gangnam Medical Center and Myongji Hospital) were analyzed.
• Mastocheck® values were compared pre- and post-surgery, with longitudinal follow-up in one cohort.
• Transitions across the diagnostic cut-off (0.0668) were evaluated.

Main Results:

• Mastocheck® values were significantly lower postoperatively in the CHA cohort (p < 0.001).
• In a paired subset, 90% of patients above the cut-off preoperatively fell below it postoperatively.
• The Myongji cohort showed a sustained decline, with 0% exceeding the cut-off at final follow-up.

Conclusions:

• Mastocheck® values consistently decrease after breast cancer surgery across independent cohorts.
• These findings support the reproducibility of postoperative decline dynamics and cut-off transitions.
• The study did not assess recurrence detection or clinical surveillance performance.