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Disparities in Outcomes in Latino Subpopulations with Localized Prostate Cancer Undergoing Radical Prostatectomy: A
Salvador Jaime-Casas1, Regina Barragan-Carrillo2, Anjaney Kothari1
1Division of Urology and Urologic Oncology, Department of Surgery, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Cancers
|March 28, 2026
Summary
Prostate cancer outcomes vary significantly among Latino men. Mexican Latinos experienced worse survival and higher recurrence rates compared to other Latino subgroups, highlighting the need for tailored approaches.
Area of Science:
- Urology
- Oncology
- Health Disparities
Background:
- Prostate cancer disproportionately affects Latino men, who face higher mortality rates.
- Existing research often aggregates Latino populations, masking critical subgroup differences.
Purpose of the Study:
- To investigate prostate cancer outcomes across distinct Latino subpopulations: Mexican, South/Central American (SCA), and Caribbean.
- To compare these outcomes against a Non-Hispanic White (NHW) reference group.
Main Methods:
- Retrospective review of localized prostate cancer patients treated with radical prostatectomy (2003-2020).
- Latino patients categorized into Mexican, SCA, or Caribbean groups.
- Statistical analysis including survival and multivariable analyses.
Main Results:
- Latino patients were younger, had higher BMI, PSA, and advanced disease risk compared to NHW.
- Mexican Latinos showed higher baseline PSA and significantly shorter overall survival and biochemical recurrence-free survival rates.
- South/Central American (SCA) subpopulation status was linked to better overall survival.
Conclusions:
- Significant disparities in prostate cancer outcomes exist within the diverse Latino population.
- Disaggregating data by specific Latino subpopulations is crucial for understanding and addressing health inequities.
- Findings emphasize the need for personalized treatment strategies considering ethnic and cultural nuances.
