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Depressive Disorders: Etiology01:27

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Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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The Relationship Between Pain and Depression in Fibromyalgia: Structural Equation Modeling and Network Analysis.

Francesco Oliva1, Mariagrazia Merola1, Alberto Olivero2

  • 1Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy.

International Journal of Environmental Research and Public Health
|March 28, 2026
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Depression plays a central role in fibromyalgia (FM), impacting pain and fatigue. Targeting depression may improve integrated care for chronic pain patients.

Keywords:
chronic paindepressionfatiguefibromyalgiapsychopathology

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Rheumatology

Background:

  • Fibromyalgia (FM) presents complex symptoms including chronic pain, fatigue, and sleep issues.
  • Psychiatric symptoms frequently co-occur with FM, complicating diagnosis and treatment.

Purpose of the Study:

  • To investigate the intricate relationships between core fibromyalgia symptoms and psychopathological factors.
  • To determine the central role of depression within the fibromyalgia symptom network.

Main Methods:

  • Cross-sectional study of 50 fibromyalgia outpatients using validated assessment tools.
  • Employed structural equation modeling (SEM) and network analysis to map symptom interconnections.

Main Results:

  • Depression emerged as a central factor in the FM symptom network, linked to emotional and physical dysfunction.
  • Fatigue significantly mediated the relationship between depression and pain.
  • Stress contributed to the overall symptom burden but was not a central network factor.

Conclusions:

  • Psychological and physical symptoms in fibromyalgia are deeply interconnected.
  • Systematic assessment of depression is a clinically relevant target for integrated chronic pain management.