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Updated: Mar 29, 2026

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MedScanGAN: Synthetic PET & CT Scan Generation Using Conditional Generative Adversarial Networks for Medical AI Data

Agorastos-Dimitrios Samaras1, Ioannis D Apostolopoulos2, Nikolaos Papandrianos1

  • 1Department of Energy Systems, University of Thessaly, 413 34 Larisa, Greece.

Bioengineering (Basel, Switzerland)
|March 28, 2026
PubMed
Summary
This summary is machine-generated.

MedScanGAN generates realistic synthetic medical images for Non-Small-Cell Lung Cancer (NSCLC) diagnosis. Augmenting datasets with these images significantly improves AI diagnostic accuracy, particularly for lung nodule detection.

Keywords:
Non-Small-Cell Lung CancerPET/CTcomputer-aided diagnosisdata augmentationdeep learninggenerative adversarial networksmedical imagingsynthetic data generation

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Area of Science:

  • Medical Imaging
  • Artificial Intelligence
  • Oncology

Background:

  • Data scarcity is a major challenge in developing AI for medical diagnosis.
  • Accurate diagnosis of Non-Small-Cell Lung Cancer (NSCLC) from medical images is critical.

Purpose of the Study:

  • To introduce MedScanGAN, a conditional Generative Adversarial Network for synthesizing high-fidelity PET and CT images of Solitary Pulmonary Nodules (SPNs).
  • To enhance computer-aided diagnosis (CADx) systems for NSCLC using generated synthetic data.

Main Methods:

  • Developed MedScanGAN, a conditional GAN with residual blocks, spectral normalization, and stabilized training.
  • Generated synthetic PET and CT images of SPNs.
  • Augmented training datasets of deep learning models (YOLOv8, VGG-16, ResNet, MobileNet) with synthetic data.

Main Results:

  • MedScanGAN generated realistic synthetic images, particularly for PET.
  • Augmenting datasets with synthetic data improved NSCLC classification performance.
  • YOLOv8 achieved 94.14% accuracy, 93.12% specificity, and 95.33% sensitivity with augmented data, a +5.8% accuracy gain.

Conclusions:

  • MedScanGAN demonstrates state-of-the-art medical image synthesis capabilities.
  • Synthetic data generated by MedScanGAN effectively improves the performance of deep learning models for NSCLC diagnosis.
  • This work bridges generative AI and clinical pulmonary oncology, offering practical value for diagnostic systems.