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Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies
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Lab-on-a-Chip and Microfluidics Technologies for Nano Drug Delivery.

Bochun Guo1,2, Yuchao Zhao3, Xunli Zhang1

  • 1School of Engineering, University of Southampton, Southampton SO17 1BJ, UK.

Bioengineering (Basel, Switzerland)
|March 28, 2026
PubMed
Summary
This summary is machine-generated.

Lab-on-a-Chip (LoC) and microfluidics enhance nano drug delivery systems (DDSs) by enabling precise control and high-throughput screening. These technologies improve nanoparticle characteristics and biological evaluation for advanced therapeutic strategies.

Keywords:
drug delivery systemslab-on-a-chipmicrofluidicsnanomedicinenanoparticle synthesis

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Area of Science:

  • Microfluidics and Nanotechnology
  • Drug Delivery Systems
  • Biomedical Engineering

Background:

  • Lab-on-a-Chip (LoC) and microfluidic technologies are revolutionizing nano drug delivery systems (DDSs).
  • These platforms offer precise control over physicochemical properties, high-throughput screening, and integrated biological evaluation.
  • Miniaturized systems are essential for advancing DDS development.

Purpose of the Study:

  • To synthesize recent advances in microfluidic principles, fabrication, and sensing for nano DDS.
  • To highlight the role of LoC systems in nanoparticle synthesis, characterization, and formulation.
  • To discuss emerging trends and future potential in integrated nano-pharmaceutics.

Main Methods:

  • Review of microfluidic principles and fabrication strategies for nano DDS.
  • Synthesis of continuous flow methods for nanoparticle production and characterization.
  • Integration of sensing modalities and organ-on-chip (OoC) models for biological evaluation.

Main Results:

  • LoC systems enhance monodispersity, reproducibility, and tunability of various nanoparticles (liposomes, polymeric, metallic).
  • Microfluidics facilitates real-time characterization and adaptive formulation of DDS.
  • Organ-on-chip models integrated with LoC enable assessment of pharmacokinetics, drug release, and systemic responses.

Conclusions:

  • The synergy between LoC engineering and nanomedicine holds transformative potential for personalized therapeutics.
  • Emerging trends like AI, stimuli-responsive materials, and 3D printing will shape future nano-pharmaceutics.
  • Addressing challenges in biocompatibility, standardization, and clinical translation is crucial for realizing LoC-based DDS potential.