Related Experiment Video
Updated: Mar 29, 2026

Constructing and Visualizing Models using Mime-based Machine-learning Framework
Published on: July 22, 2025
Learning Continuous Decomposable Models Using Mutual Information and Statistical Copulas
Luiz Desuó Neto1, Henrique de Oliveira Caetano2, Matheus de Souza Sant'Anna Fogliatto2
1Department of Electrical Engineering, São Paulo State University (UNESP), Guaratinguetá 12516-410, SP, Brazil.
Abstract:
Learning dependence graphs from multivariate continuous data is challenging when marginal distributions are heterogeneous, since likelihood-based nonparametric scores can be sensitive to smoothing choices and can confound marginal irregularities, including non-identifiability, with dependence. This work studies structure learning in the class of decomposable (chordal) Markov random fields, where junction tree factorizations enable tractable inference and local score updates. Our first contribution is a theoretical result showing that, under decomposability, mutual information can be expressed as a difference of clique/separator copula entropies, yielding a dependence-only decomposition aligned with the clique/separator structure. Building on this identity, we define an information-theoretic objective for decomposable graphs with a complexity penalty that preserves clique/separator additivity, and we derive closed-form local score differences for chordality-preserving single-edge insertions and deletions. To make the score computable from data, we instantiate clique/separator copula entropies using pseudo-observations and a probit-transformed kernel density estimator with predictive log score evaluation to mitigate boundary effects on the unit hypercube. The resulting nonparametric greedy procedure improves edge recovery accuracy on synthetic chordal benchmarks compared with a likelihood-driven nonparametric baseline, and it produces interpretable dependence summaries on an airway epithelial gene expression dataset. Concretely, this paper contributes (1) a decomposable mutual information identity via clique/separator copula entropies, (2) a copula information score with an additive complexity penalty for decomposable graphs, (3) a closed-form local score, enabling greedy chordal add or delete search, (4) a practical nonparametric copula entropy estimation pipeline, and (5) empirical gains on synthetic and real data.
Related Concept Videos
Multicompartment Models: Overview
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Statistical Analysis: Overview
One of the most commonly used statistical quantifiers is the mean, which is the ratio between the sum of the numerical values of all results and the...
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...
Mechanistic Models: Overview of Compartment Models
Mechanistic Models: Compartment Models in Individual and Population Analysis

