Thermal and Kinetic Analysis of Benzimidazole Derivatives: Fenbendazole, Mebendazole, and Flubendazole

This study presents a comparative thermal and kinetic analysis of three benzimidazole derivatives used in the pharmaceutical field: fenbendazole, mebendazole, and flubendazole. The investigations were carried out using thermoanalytical methods, including thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), in order to evaluate thermal stability, decomposition stages, and to calculate kinetic parameters. The obtained data were processed using isoconversional methods (Ozawa-Flynn-Wall, and Friedman) and non-parametric method (NPK) to determine activation energies and degradation mechanisms. The results revealed significant differences among the three compounds regarding their thermal stability and decomposition behavior, influenced by molecular structure and aromatic substituents. Furthermore, the comparative analysis provides valuable insights for optimizing technological processes, assessing stability in pharmaceutical formulations, and expanding research on the therapeutic potential of these compounds, including in oncological studies. Overall, the study contributes to a deeper understanding of the relationship between chemical structure and thermal stability in benzimidazole derivatives.