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Updated: Mar 29, 2026

Construction of Local Field Potential Microelectrodes for in vivo Recordings from Multiple Brain Structures Simultaneously

Construction of Local Field Potential Microelectrodes for in vivo Recordings from Multiple Brain Structures Simultaneously

Published on: March 14, 2022

A Comb-Shaped Flexible Microelectrode Array for Simultaneous Multi-Scale Cortical Recording.

Suyi Zhang^1,2, Jin Shan^1,2, Shiya Lv^1,2

¹State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190, China.

|March 28, 2026

Summary

This summary is machine-generated.

Researchers developed a flexible neural probe array for high-fidelity brain recordings. This multi-modal interface captures electrocorticography (ECoG) and neural spikes, advancing neuroscience and brain-computer interface development.

Keywords:

audiovisual cross-modal stimulation brain–computer interface (BCI)cortical microcircuit flexible micro-electrode array multi-scale neural recording

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Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

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Last Updated: Mar 29, 2026

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Author Spotlight: Low-Cost Electroencephalographic Recording System Combined with a Millimeter-Sized Coil to Transcranially Stimulate the Mouse Brain In Vivo

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Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

Published on: February 12, 2020

Area of Science:

Neuroscience
Biomedical Engineering
Neural Engineering

Background:

Advanced neural interfaces are critical for systems neuroscience and brain-computer interfaces (BCIs).
Existing technologies often face limitations in resolution, signal fidelity, or invasiveness.

Purpose of the Study:

To design and fabricate a novel 128-channel flexible micro-electrode array.
To enable simultaneous multi-modal neural recordings (ECoG, LFP, spikes).
To evaluate the device's performance in vivo for high-resolution electrophysiology.

Main Methods:

Fabrication of a comb-shaped flexible micro-electrode array on a Parylene substrate.
Modification of electrode sites with platinum black nanoparticles to reduce impedance.
In vivo electrophysiological recordings in rat models.

Main Results:

Successful simultaneous recording of electrocorticography (ECoG), local field potentials (LFPs), and neuronal action potentials (spikes).
Acquisition of high-fidelity signals with micro-scale spatial resolution, including opposing LFP trends.
Demonstrated reliable neural activity capture during cross-modal sensory stimulation.

Conclusions:

The developed flexible micro-electrode array is an effective tool for multi-scale electrophysiology.
The device balances high spatial resolution and signal quality with minimal invasiveness.
This technology holds significant potential for fundamental neuroscience research and neural engineering applications.