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Updated: Mar 29, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
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The Silent Pandemic: Antifungal Resistance and the Future of Invasive Fungal Disease Management

Ruchika Bagga1,2, Kumudhavalli Kavanoor Sridhar3

  • 1Department of Pathobiology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 3K7, Canada.

Microorganisms
|March 28, 2026
PubMed

Insights

Antifungal resistance (AFR) is a growing threat in invasive fungal diseases (IFDs). This review covers AFR epidemiology, molecular mechanisms, diagnostics, and new treatments to guide clinicians.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Invasive fungal diseases (IFDs) pose a significant global health challenge.
  • Antifungal resistance (AFR) is rapidly emerging, complicating treatment.
  • Current antifungal arsenal is limited, necessitating new strategies.

Purpose of the Study:

  • To provide a comprehensive overview of the current landscape of antifungal resistance (AFR).
  • To offer actionable insights for clinical practitioners managing IFDs.
  • To synthesize clinical and microbiological perspectives on AFR.

Main Methods:

  • Review of contemporary clinical and microbiological data on AFR.
  • Examination of epidemiology of key fungal pathogens.
  • Analysis of molecular mechanisms driving resistance.
  • Appraisal of diagnostic tools and therapeutic strategies.

Main Results:

  • Identified critical pathogens: Candida auris, Candida parapsilosis, Aspergillus fumigatus.
  • Dissected molecular mechanisms: ERG11, cyp51A mutations, epigenetic changes.
  • Highlighted diagnostic gaps and the role of molecular assays.
  • Evaluated novel antifungal agents and stewardship principles.

Conclusions:

  • AFR is a complex challenge requiring integrated approaches.
  • Rapid diagnostics and novel therapeutics are crucial for managing IFDs.
  • Antifungal stewardship and One Health interventions are essential to combat resistance.
Keywords:
Aspergillus fumigatusCandidozyma aurisantifungal resistanceantifungal stewardshipmolecular diagnostics

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