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Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
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Advancements in Therapeutic Deep Eutectic Solvents as Multifunctional Transdermal Delivery Systems.
1Gansu Pharmaceutical Industry Innovation Research Institute, Gansu University of Chinese Medicine, Lanzhou 730101, China.
Pharmaceutics
|March 28, 2026
Summary
Therapeutic deep eutectic solvents (TheDES) offer a green solution to enhance drug delivery through the skin barrier. These novel solvents improve solubility and transdermal flux, overcoming key challenges in drug development.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Dermatology
Background:
- The stratum corneum (SC) presents a significant barrier to transdermal drug delivery.
- Many new drug candidates suffer from poor solubility and low permeability.
- Novel drug delivery vehicles are essential to overcome these limitations.
Purpose of the Study:
- To review the fundamentals, mechanisms, and applications of Therapeutic Deep Eutectic Solvents (TheDES).
- To explore TheDES's role in enhancing solubility and transdermal flux of Active Pharmaceutical Ingredients (APIs).
- To discuss advanced dosage forms and therapeutic applications of TheDES.
Main Methods:
- Literature review of physicochemical properties of TheDES.
- Analysis of permeation enhancement mechanisms, including the lipid exchange effect.
- Examination of transition to advanced formulations like eutectogels and nanoemulsions.
Main Results:
- TheDES significantly enhance API solubility and transdermal flux.
- The "lipid exchange" effect is a newly identified mechanism for permeation enhancement.
- TheDES can be formulated into advanced delivery systems like eutectogels and nanoemulsions.
Conclusions:
- TheDES represent a promising green technology for improving transdermal drug delivery.
- Applications span pain management, infectious diseases, and chronic conditions.
- Further research into safety and computational modeling is warranted.
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